Functional Information in Coronary Artery Disease: The Case of Computed Tomography Myocardial Perfusion

Current Cardiology Reports
Klaus F KofoedJesper J Linde

Abstract

To review methodological and logistical aspects of CT myocardial perfusion, current clinical evidence and possible future directions, with specific focus on use in patients with coronary artery disease (CAD). CT myocardial perfusion imaging may be performed as an add-on to standard coronary CT angiography (CCTA), to identify regions of myocardial hypoperfusion, at rest and during adenosine stress. The principle of measurement is well-validated in animal experimental models, and CT myocardial perfusion imaging has a high degree of concordance with already clinically available perfusion imaging methods. Combining CCTA and CT myocardial perfusion imaging increases the diagnostic accuracy to identify patients with CAD associated with ischemia. In patients suspected of CAD, CCTA frequently detects coronary atherosclerotic lesions, in which revascularization could be clinically beneficial. CT myocardial perfusion imaging may be helpful to identify coronary lesions associated with myocardial ischemia, and thus potentially suitable for coronary intervention.

References

Jul 1, 1974·The American Journal of Cardiology·K L Gould, K Lipscomb
Nov 30, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Klaus F KofoedHenning Kelbaek
Jul 4, 2006·Journal of the American College of Cardiology·Richard T GeorgeAlbert C Lardo
Nov 17, 2007·Investigative Radiology·Richard T GeorgeAlbert C Lardo
Jan 16, 2009·The New England Journal of Medicine·Pim A L ToninoUNKNOWN FAME Study Investigators
May 6, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nasser M MalyarErik L Ritman
Dec 7, 2011·The International Journal of Cardiovascular Imaging·J Tobias KühlKlaus Fuglsang Kofoed
Dec 8, 2011·Journal of Cardiovascular Computed Tomography·Elisabeth ArnoldiU Joseph Schoepf
Aug 29, 2012·The New England Journal of Medicine·Bernard De BruyneUNKNOWN FAME 2 Trial Investigators
Dec 12, 2012·Journal of the American College of Cardiology·Sharmila DorbalaLeslee J Shaw
Apr 3, 2013·Journal of Cardiovascular Computed Tomography·Christina ByrneKlaus Fuglsang Kofoed
Jun 22, 2013·Radiology·Armin M HuberErnst Rummeny
Dec 25, 2013·European Heart Journal·Filippo CreaCathleen Noel Bairey Merz
Sep 10, 2014·The International Journal of Cardiovascular Imaging·Jesper James LindeKlaus Fuglsang Kofoed
Mar 17, 2015·The New England Journal of Medicine·Pamela S DouglasUNKNOWN PROMISE Investigators
Mar 17, 2015·Cardiovascular Diagnosis and Therapy·Gaston A Rodriguez-GranilloRicardo C Cury
Apr 16, 2016·Journal of the American College of Cardiology·Michelle C WilliamsUNKNOWN SCOT-HEART Investigators
Oct 9, 2016·The International Journal of Cardiovascular Imaging·Jesper J LindeKlaus F Kofoed
Oct 25, 2016·Journal of Cardiovascular Computed Tomography·Mathias Holm SørgaardJawdat Abdulla
Jan 23, 2017·JACC. Cardiovascular Imaging·Adriaan CoenenKoen Nieman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.