Functional interaction between 5-HT(6) receptors and hypothalamic-pituitary-adrenal axis: cognitive implications

Neuropharmacology
Beatriz MarcosMaria J Ramírez

Abstract

The serotonin 5-HT(6) receptor has become a promising target for the treatment of neuropsychological diseases, such as affective disorders. Increasing evidence implicates stress and its effector system, the hypothalamic-pituitary-adrenal (HPA) axis, in the neurobiology of depression. In addition, there are important memory disturbances in stress-related psychiatric disorders that have been associated to an impairment of the HPA axis reactivity. The aim of the present work is to study the functional interactions between 5-HT(6) receptors and HPA axis. In a situation of increased HPA axis responsiveness (maternal separation, MS) no differences were found in the expression of 5-HT(6) gene in the hippocampus or frontal cortex, although serotonin levels were higher in the frontal cortex of MS rats. 5-HT(6) receptor mRNA expression increased significantly in the hippocampus in a situation of decreased glucocorticoid levels, such as adrenalectomy. Cognitive deficits associated to HPA dysfunction, such those found in the MS model, were fully reversed by administration of SB271046, a selective 5-HT(6) receptor antagonist. A chronic treatment with SB271046 did not modify CRF mRNA levels in the hypothalamus, but there was a higher glucoco...Continue Reading

References

Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Apr 1, 1997·Brain Research. Molecular Brain Research·J L YauJ R Seckl
Dec 17, 1998·The Journal of Endocrinology·L ArboreliusC B Nemeroff
Jun 9, 1999·The American Journal of Psychiatry·K S KendlerC A Prescott
Aug 6, 2000·British Journal of Pharmacology·C RoutledgeD N Middlemiss
Mar 20, 2001·Nature Reviews. Neuroscience·M W Brown, J P Aggleton
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·M S OitzlE R de Kloet
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sudabeh Shirazi-SouthallGeorge G Nomikos
Jun 9, 2004·Neurobiology of Learning and Memory·Rebecca S HammondRobert W Stackman
Sep 15, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·H M van Praag
May 14, 2005·Nature Reviews. Neuroscience·E Ron de KloetFlorian Holsboer
Jul 12, 2005·Pharmacology & Therapeutics·Ellen S Mitchell, John F Neumaier
Jan 24, 2006·Nature Reviews. Neuroscience·Olivier Berton, Eric J Nestler
Apr 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Benno RoozendaalJames L McGaugh
Feb 20, 2007·Psychoneuroendocrinology·Bárbara AisaMaria J Ramírez
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Per SvenningssonPaul Greengard

❮ Previous
Next ❯

Citations

Aug 22, 2014·Acta Neuropsychiatrica·Aline H MelloGislaine T Rezin
Nov 4, 2008·Neurochemical Research·Gislaine T RezinEmilio L Streck
Nov 11, 2008·Behavioural Brain Research·Carl W StevensonCharles A Marsden
Sep 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Antonio Drago, Alessandro Serretti
Dec 15, 2010·CNS Neuroscience & Therapeutics·Katja Wingenfeld, Oliver T Wolf
Sep 10, 2009·The International Journal of Neuropsychopharmacology·Beatriz MarcosMaria J Ramirez
Jan 29, 2011·Pharmacological Reports : PR·Katarzyna FijałMałgorzata Filip
Apr 24, 2013·Alzheimer's Research & Therapy·María Javier Ramírez
Mar 12, 2019·Experimental Neurobiology·Soon-Hee KimHyewhon Rhim
Mar 22, 2015·Journal of Cell Science·Chang Man HaSunghoe Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.