Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1

Neuron
Gonzalo E TorresM G Caron

Abstract

PDZ domain-containing proteins play an important role in the targeting and localization of synaptic membrane proteins. Here, we report an interaction between the PDZ domain-containing protein PICK1 and monoamine neurotransmitter transporters in vitro and in vivo. In dopaminergic neurons, PICK1 colocalizes with the dopamine transporter (DAT) and forms a stable protein complex. Coexpression of PICK1 with DAT in mammalian cells and neurons in culture results in colocalization of the two proteins in a cluster pattern and an enhancement of DAT uptake activity through an increase in the number of plasma membrane DAT. Deletion of the PDZ binding site at the carboxyl terminus of DAT abolishes its association with PICK1 and impairs the localization of the transporter in neurons. These findings indicate a role for PDZ-mediated protein interactions in the localization, expression, and function of monoamine transporters.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T B UsdinB J Hoffman
Jan 1, 1993·Annual Review of Neuroscience·S G Amara, M J Kuhar
Feb 1, 1993·Trends in Pharmacological Sciences·B Giros, M G Caron
Jun 1, 1997·Current Opinion in Neurobiology·H C KornauM B Kennedy
Nov 18, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M Sheng, M Wyszynski
Dec 5, 1997·Brain Research. Molecular Brain Research·N Takahashi, G Uhl
Jan 24, 1998·The Journal of Biological Chemistry·J StaudingerE N Olson
Jan 27, 1998·The Journal of Biological Chemistry·S RamamoorthyR D Blakely
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·S R JonesM G Caron
Aug 4, 1998·Current Opinion in Neurobiology·R J O'BrienR L Huganir
Aug 26, 1998·Drug and Alcohol Dependence·S G Amara, M S Sonders
Mar 17, 1999·The Journal of Clinical Investigation·A S Fanning, J M Anderson
Nov 17, 1999·Proceedings of the Society for Experimental Biology and Medicine·E D ClarksonK N Prasad
Mar 29, 2000·The Journal of Biological Chemistry·P ManivetJ M Launay
Apr 25, 2000·Neuron·J D Berke, S E Hyman

❮ Previous
Next ❯

Citations

Dec 18, 2013·Pflügers Archiv : European journal of physiology·Gary RudnickFrancois Verrey
Sep 18, 2007·Journal of Molecular Neuroscience : MN·Anna MoszczynskaFang Liu
Mar 17, 2004·Current Opinion in Pharmacology·Marco I González, Michael B Robinson
Nov 13, 2003·European Journal of Pharmacology·Shigeo Kitayama, Toshihiro Dohi
Nov 13, 2003·European Journal of Pharmacology·Margaret E Gnegy
Nov 13, 2003·European Journal of Pharmacology·Kristopher M Kahlig, Aurelio Galli
Nov 13, 2003·European Journal of Pharmacology·Ole V Mortensen, Susan G Amara
Jul 20, 2002·Archives of Biochemistry and Biophysics·Patricia A Bauman, Randy D Blakely
Jun 20, 2003·Neuropharmacology·Kumlesh K DevGiorgio Rovelli
Jun 20, 2003·Neuropharmacology·Kumlesh K DevHerman van der Putten
Oct 24, 2001·Trends in Neurosciences·S L DekenM W Quick
Jul 10, 2002·Neuroscience Research·Atsushi MoriYasuhide Mitsumoto
Feb 8, 2003·Brain Research. Molecular Brain Research·James D FosterRoxanne A Vaughan
Dec 31, 2003·Molecular and Cellular Neurosciences·Valentina SavchenkoRandy D Blakely
Jul 30, 2011·Biochemistry·Jonathan J Sager, Gonzalo E Torres
Dec 2, 2004·Nature Reviews. Drug Discovery·Kumlesh K Dev
Sep 21, 2004·Nature Reviews. Neuroscience·Eunjoon Kim, Morgan Sheng
Nov 30, 2005·Molecular Psychiatry·K FujiiA Sawa
Jul 30, 2010·Organic & Biomolecular Chemistry·Anders BachKristian Strømgaard
Jun 18, 2002·Journal of Neurochemistry·Sonja SucicLesley J Bryan-Lluka
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mette RathjeKenneth L Madsen
Aug 12, 2004·Neuroreport·Chen-Jee HongShih-Jen Tsai
Dec 27, 2011·Cold Spring Harbor Perspectives in Biology·Randy D Blakely, Robert H Edwards
Apr 29, 2006·Genes, Brain, and Behavior·R MaiyaR D Mayfield
Dec 23, 2008·The Journal of Pharmacology and Experimental Therapeutics·Rong ChenMargaret E Gnegy
Aug 24, 2010·Molecular Interventions·Charles P Mercado, Fusun Kilic
Nov 5, 2002·Annual Review of Pharmacology and Toxicology·Richard Nass, Randy D Blakely
Jan 12, 2007·Neuro-Signals·Junyu Xu, Jun Xia
Mar 5, 2009·The Journal of Clinical Investigation·Nan XiaoJun Xia
Jun 24, 2009·BMC Neuroscience·Heinrich J G MatthiesRandy D Blakely
May 8, 2009·Molecular Brain·Heping ZhangFang Liu
Dec 16, 2005·The AAPS Journal·Lankupalle D Jayanthi, Sammanda Ramamoorthy
Dec 21, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Toshihiro DohiKatsuya Morita

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.