Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP)

Microscopy Research and Technique
Walter BornJan A Fischer

Abstract

Adrenomedullin (AM), alpha- and beta-calcitonin gene-related peptide (CGRP), calcitonin (CT), and amylin are homologous polypeptides with overlapping biological actions such as vasodilatation and inhibition of bone resorption. They are brought about through receptors that include the CT receptor (CTR) and an initially orphan CT receptor-like receptor (CRLR) in association with receptor-activity-modifying proteins (RAMP)1, -2, and -3. Co-expression of CRLR with RAMP1 or -2 revealed CGRP or AM receptors, respectively. The CTR interacts with CT and does not require a known RAMP for functional expression. The same CTR is a CGRP/amylin or an amylin receptor upon co-expression with RAMP1 or -3, respectively. Interactions between CRLR and RAMP are thought to be required for their delivery to the cell surface. There, heterodimeric complexes between CRLR or CTR and the corresponding RAMP reveal high-affinity receptors for AM, CGRP, and amylin. Here we review the current knowledge on interactions of G protein-coupled receptors with defined associated proteins.

References

Jun 15, 1990·Biochemical and Biophysical Research Communications·J S HothersallS Wimalawansa
Oct 16, 1989·Biochemical and Biophysical Research Communications·D KreutterK M Andrews
Jul 31, 1989·Biochemical and Biophysical Research Communications·H K DattaI MacIntyre
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P WestermarkK H Johnson
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G J CooperK B Reid
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G J CooperK B Reid
Dec 7, 1968·Nature·R NeherI MacIntyre
Jul 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Jan 5, 1995·Biochemical and Biophysical Research Communications·B FlühmannW Born
Apr 15, 1994·Biochemical and Biophysical Research Communications·Y IshizakaT Eto
Oct 15, 1993·Biochemical and Biophysical Research Communications·C NukiA Wada
Apr 30, 1993·Biochemical and Biophysical Research Communications·K KitamuraT Eto
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·A E LuebkeI M Dickerson
May 10, 1996·The Journal of Biological Chemistry·N AiyarY Li
Jun 1, 1996·General Pharmacology·S D Brain, H Cambridge
Nov 8, 1996·The Journal of Biological Chemistry·C RomanoK L O'Malley
Feb 23, 1999·Biochemistry·H H HoM C Gershengorn

❮ Previous
Next ❯

Citations

Aug 19, 2003·European Journal of Pharmacology·Christian JuanedaRémi Quirion
Aug 31, 2006·Sports Biomechanics·Spiros PrassasWilliam A Sands
Aug 27, 2009·Sports Biomechanics·Gareth Irwin, David G Kerwin
Sep 3, 2010·Sports Biomechanics·Elizabeth BradshawBrad Aisbett
May 24, 2005·Nature Immunology·Kim A BrogdenMichael Zasloff
Nov 14, 2003·Canadian Journal of Physiology and Pharmacology·Cathy NguyenNathalie Vergnolle
Mar 1, 2008·Archives of Biochemistry and Biophysics·Antje K HuebnerThorsten Schinke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.