Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.

The Journal of Biological Chemistry
Young-Don KwakFrancesca-Fang Liao

Abstract

The contribution of zinc-mediated neuronal death in the process of both acute and chronic neurodegeneration has been increasingly appreciated. Phosphatase and tensin homologue, deleted on chromosome 10 (PTEN), the major tumor suppressor and key regulator of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, plays a critical role in neuronal death in response to various insults. NEDD4-1-mediated PTEN ubiquitination and subsequent degradation via the ubiquitin proteosomal system have recently been demonstrated to be the important regulatory mechanism for PTEN in several cancer types. We now demonstrate that PTEN is also the key mediator of the PI3K/Akt pathway in the neuronal response to zinc insult. We used primary cortical neurons and neuroblastoma N2a cells to show that zinc treatment results in a reduction of the PTEN protein level in parallel with increased NEDD4-1 gene/protein expression. The reduced PTEN level is associated with an activated PI3K pathway as determined by elevated phosphorylation of both Akt and GSK-3 as well as by the attenuating effect of a specific PI3K inhibitor (wortmannin). The reduction of PTEN can be attributed to increased protein degradation via the ubiquitin proteosomal system, as we show NEDD...Continue Reading

References

Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Aug 29, 1983·Brain Research·C J FredericksonJ B Kirkpatrick
Jan 1, 1993·Neuron·J H WeissD W Choi
Oct 23, 1997·The Journal of Biological Chemistry·X HuangA I Bush
Sep 5, 1998·The American Journal of Physiology·J M SametW Reed
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·M M GeorgescuH Hanafusa
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·X WuY E Whang
Jun 24, 2000·Molecular and Cellular Biology·F VazquezW R Sellers
Feb 8, 2002·Molecular Neurobiology·J Y Koh
Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·David C WhitemanCharis Eng
May 14, 2003·The Journal of Biological Chemistry·Weidong WuAndrew J Ghio
Oct 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Chang-Hyuk KwonSuzanne J Baker
Apr 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ke NingQi Wan
May 5, 2004·The Journal of Biological Chemistry·Andrew B FotiaSharad Kumar
Sep 10, 2004·The Journal of Biological Chemistry·Fumiaki OkaharaTomohiko Maehama
Jan 20, 2005·Nature Neuroscience·Krystyna KelemanBarry J Dickson
May 14, 2005·Nature Reviews. Neuroscience·Christopher J FredericksonAshley I Bush
Jul 12, 2005·The Journal of Clinical Investigation·Tomohisa NagoshiAnthony Rosenzweig
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ping HanFrancesca-Fang Liao
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jing Qian, Jeffrey L Noebels
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yukitoshi IzumiCharles F Zorumski
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qian SangSeong-Seng Tan
Jul 11, 2006·The Journal of Biological Chemistry·Koichi OkumuraFrank B Furnari
Aug 4, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tatiana SorkinaAlexander Sorkin
Jan 16, 2007·Cell·Xinjiang WangXuejun Jiang
Jan 16, 2007·Cell·Lloyd C TrotmanPier Paolo Pandolfi
Feb 27, 2007·The Journal of Biological Chemistry·Jenny EkbergDavid J Adams
Dec 14, 2007·Developmental Neuroscience·Michiel T van Diepen, Britta J Eickholt
Apr 9, 2008·Current Opinion in Cell Biology·Dervis A M Salih, Anne Brunet
May 6, 2008·Cell·Leonardo SalmenaPier Paolo Pandolfi
Jun 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fatemeh FouladkouDaniela Rotin
Jun 24, 2008·FEBS Letters·Shin-Rong Hwang, Vivian Hook
Sep 25, 2008·Science Signaling·Xiao R CaoBaoli Yang
Nov 26, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Sung Soo KimSug Hyung Lee

❮ Previous
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Citations

Apr 13, 2013·Trends in Cell Biology·Adam Naguib, Lloyd C Trotman
Dec 6, 2011·The Journal of Biological Chemistry·Clarence A DunnPaul D Lampe
Nov 12, 2010·Molecular Neurodegeneration·Young-Don KwakFrancesca-Fang Liao
Dec 12, 2012·Journal of Cell Science·Yuji ShiXuejun Jiang
Aug 10, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Young-Don KwakFrancesca-Fang Liao
Dec 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lindsay A SchwarzGentry N Patrick
Mar 12, 2013·Neural Plasticity·Andrew M Hamilton, Karen Zito
Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hung-En HsiaHiroshi Kawabe
Aug 29, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Zhelong Xu, Juan Zhou
Dec 21, 2014·Gene·Natasha Anne Boase, Sharad Kumar
Jan 18, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Antonio ContestabileBarbara Monti
May 9, 2012·Molecular and Cellular Neurosciences·Kimberly J ChristieDouglas W Zochodne
Jan 18, 2011·Trends in Pharmacological Sciences·Nick R Leslie, Michelangelo Foti
Mar 19, 2013·Neuroscience·K J Christie, D Zochodne
Feb 20, 2013·Brain Research·Kang-Jian SunJi-Xin Shi
Apr 22, 2016·Diabetes, Obesity & Metabolism·X-D YangY-Y Yang
Jul 28, 2016·Biochemical and Biophysical Research Communications·Rui YangGuojun Zhang
Oct 25, 2017·International Journal of Molecular Sciences·Martina MaywaldLothar Rink
Aug 2, 2017·The American Journal of Chinese Medicine·Jing LiZuo-Hui Shao
Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Seon-Ae JeonJe-Yoel Cho
Feb 11, 2016·Biochemical Society Transactions·Nick R LeslieHelen M Wise
Dec 4, 2019·Cell Death & Disease·Xi HuangZhen Cai
Jan 17, 2019·American Journal of Physiology. Renal Physiology·Clintoria R WilliamsRobert S Hoover

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