Functional interactions within the parahippocampal region revealed by voltage-sensitive dye imaging in the isolated guinea pig brain

Journal of Neurophysiology
G R BiellaV Gnatkovsky

Abstract

The massive transfer of information from the neocortex to the entorhinal cortex (and vice versa) is hindered by a powerful inhibitory control generated in the perirhinal cortex. In vivo and in vitro experiments performed in rodents and cats support this conclusion, further extended in the present study to the analysis of the interaction between the entorhinal cortex and other parahippocampal areas, such as the postrhinal and the retrosplenial cortices. The experiments were performed in the in vitro isolated guinea pig brain by a combined approach based on electrophysiological recordings and fast imaging of optical signals generated by voltage-sensitive dyes applied to the entire brain by arterial perfusion. Local stimuli delivered in different portions of the perirhinal, postrhinal, and retrosplenial cortex evoked local responses that did not propagate to the entorhinal cortex. Neither high- and low-frequency-patterned stimulation nor paired associative stimuli facilitated the propagation of activity to the entorhinal region. Similar stimulations performed during cholinergic neuromodulation with carbachol were also ineffective in overcoming the inhibitory network that controls propagation to the entorhinal cortex. The pharmacol...Continue Reading

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Citations

Aug 16, 2011·Cerebral Cortex·Gunes UnalDenis Paré
Apr 7, 2015·Journal of Neuroscience Methods·Marco de CurtisLaura Uva
Mar 23, 2011·Progress in Neurobiology·John Kealy, Sean Commins
May 1, 2021·Experimental Neurology·Laura UvaMarco de Curtis
Aug 10, 2021·Frontiers in Cellular Neuroscience·Noemi BininiGerardo Rosario Biella

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