Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery

International Journal of Nanomedicine
Tingting XuFeng Cao

Abstract

To enhance ocular bioavailability, the traditional strategies have focused on prolonging precorneal retention and improving corneal permeability by nano-carriers with positive charge, thiolated polymer, absorption enhancer and so on. Glycylsarcosine (GS) as an active target ligand of the peptide tranpsporter-1 (PepT-1), could specific interact with the PepT-1 on the cornea and guide the nanoparticles to the treating site. The objective of the study was to explore the active targeting intercalated nanocomposites based on chitosan-glutathione-glycylsarcosine (CG-GS) and layered double hydroxides (LDH) as novel carriers for the treatment of mid-posterior diseases. CG-GS-LDH intercalated nanocomposites were prepared by the coprecipitation hydrothermal method. In vivo precorneal retention study, ex vivo fluorescence images, in vivo experiment for distribution and irritation were studied in rabbits. The cytotoxicity and cellular uptake were studied in human corneal epithelial primary cells (HCEpiC). CG-GS-LDH nanocomposites were prepared successfully and characterized by FTIR and XRD. Experiments with rabbits showed longer precorneal retention and higher distribution of fluorescence probe/model drug. In vitro cytological study, CG-GS...Continue Reading

Citations

Jul 10, 2018·Expert Opinion on Drug Delivery·Yanyan WangFeng Cao
May 8, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Soeun GimMartina Delbianco
Dec 12, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Danushika C ManatungaK M Nalin de Silva
Jul 2, 2020·International Journal of Nanomedicine·Yan WangQi Li
Nov 14, 2021·Advanced Science·Nathalie HockAndreas Bernkop-Schnürch

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Methods Mentioned

BETA
infrared spectroscopy
X-ray
flow cytometry
blood collection
1
transmission electron micrography

Software Mentioned

PKsolver

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