Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood

ACS Chemical Neuroscience
Vera NiederkoflerSusan M Dymecki

Abstract

The complex integration of neurotransmitter signals in the nervous system contributes to the shaping of behavioral and emotional constitutions throughout development. Imbalance among these signals may result in pathological behaviors and psychiatric illnesses. Therefore, a better understanding of the interplay between neurotransmitter systems holds potential to facilitate therapeutic development. Of particular clinical interest are the dopaminergic and serotonergic systems, as both modulate a broad array of behaviors and emotions and have been implicated in a wide range of affective disorders. Here we review evidence speaking to an interaction between the dopaminergic and serotonergic neuronal systems across development. We highlight data stemming from developmental, functional, and clinical studies, reflecting the importance of this transmonoaminergic interplay.

References

Sep 27, 1978·Anatomy and Embryology·P Levitt, R Y Moore
Jan 1, 1992·Physiological Reviews·B L Jacobs, E C Azmitia
Jan 15, 1986·The Journal of Comparative Neurology·H ImaiS T Kitai
Mar 1, 1988·The Journal of Comparative Neurology·A KalsbeekH B Uylings
Mar 12, 1985·European Journal of Pharmacology·D J Balfour, T T Iyaniwura
Mar 1, 1968·The Journal of Heredity·D S Varnum, L C Stevens
May 1, 1971·British Journal of Pharmacology·G R Breese, T D Traylor
Jul 1, 1982·Brain Research Bulletin·J H Fallon, S E Loughlin
Jul 1, 1982·Brain Research Bulletin·E H Lee, M A Geyer
Feb 1, 1984·Neuroscience·E H Lee, M A Geyer
Aug 1, 1984·Pharmacology, Biochemistry, and Behavior·E H Lee, M A Geyer
Jun 1, 1983·Neuroscience·R Marchand, L J Poirier
May 26, 1995·Brain Research. Developmental Brain Research·H KawanoI Nagatsu
Nov 1, 1995·Genes & Development·I MatsuoS Aizawa
Jan 1, 1993·Experimental Brain Research·P GasparJ Colombo
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·F PettyM Moeller
May 15, 1993·The Journal of Comparative Neurology·D C German, K F Manaye

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Citations

Jul 15, 2015·ACS Chemical Neuroscience·Anne M Andrews
Jul 14, 2016·BMC Neurology·Ursula WernekeMichael Ott
Aug 30, 2016·Nature Neuroscience·Jean-Francois PoulinRajeshwar Awatramani
Dec 28, 2016·The Journal of Veterinary Medical Science·Naoko OhtaniHiroshi Yokota
Nov 1, 2017·Frontiers in Systems Neuroscience·Janna NiensThomas D Riemensperger
Jul 19, 2018·Frontiers in Neuroscience·Zvi R ShapiroMatthew S Matell
Dec 24, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adele StewartRandy D Blakely
Jun 20, 2018·International Journal of Molecular Sciences·Ameya Sanjay KastureMichael Freissmuth
Feb 10, 2021·Journal of Neural Transmission·Charline JanschKlaus-Peter Lesch
Feb 23, 2021·Journal of Psychiatric Research·Nicolas HoertelJean-François Costemale-Lacoste
Mar 7, 2021·Trends in Neurosciences·Kate Z PetersRaffaella Tonini
Jan 14, 2020·Pharmacology & Therapeutics·Eiji SugiyamaYuki Sugiura
Jun 26, 2021·Biosensors & Bioelectronics·Elisa CastagnolaXinyan Tracy Cui
Jul 10, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica J WalshRobert C Malenka

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