PMID: 15374455Mar 1, 1991Paper

Functional interrelationships in aging processes: alterations and reversibility

Archives of Gerontology and Geriatrics
Lucio PiantanelliA Zaia

Abstract

The problem of assessing the relevance of the reversibility of age-related functional alterations for aging studies has been presented. Transduction mechanisms of adrenergic stimulation have been chosen as the target of age-related changes and thymus as the effector of some corrective interventions performed at advanced age. Both alterations of adrenoceptor characteristics and their reversibility have been reviewed. beta-adrenoceptors have been studied in organs bearing only one subtype of receptors or both, revealing an age-related decrease in density only in the beta1-subtype. It has been shown that a similar age-related decrease is present in alpha1-adrenoceptor density. Such alterations are corrected by grafting a neonatal thymus into old mice. On the contrary, thymus fails to correct the alteration of T4-induced upregulation of beta-adrenoceptors indicating some limits to its corrective effect when the net of functional interrelationships becomes relatively complex. Both failures and successes of thymic grafts and thymic extracts in reversing age-related changes are discussed taking into account the effects induced on the life span of the animals. Different unsolved problems stemming from the previous considerations are al...Continue Reading

References

Mar 1, 1978·Mechanisms of Ageing and Development·L PiantanelliN Fabris
Jan 1, 1976·Gerontology·K S Brown, W F Forbes
Jul 1, 1975·Journal of Gerontology·T FurukawaS Takasugi
Jan 1, 1989·Archives of Gerontology and Geriatrics·C ViticchiL Piantanelli
Jul 1, 1985·Archives of Gerontology and Geriatrics·L PiantanelliC Viticchi
Dec 1, 1986·Archives of Gerontology and Geriatrics·L PiantanelliA Basso
Dec 1, 1988·Mechanisms of Ageing and Development·E NakamuraT Ozeki
Jul 10, 1987·Science·J W Rowe, R L Kahn
Jul 1, 1987·Neurobiology of Aging·R A Miller
Sep 1, 1980·Mechanisms of Ageing and Development·L PiantanelliC Viticchi
Nov 1, 1980·Mechanisms of Ageing and Development·G HofeckerH Niedermüller

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Citations

Dec 4, 2009·Rejuvenation Research·Andrea BassoEugenio Mocchegiani
Dec 26, 1992·Annals of the New York Academy of Sciences·A ZaiaL Piantanelli
Nov 25, 1994·Annals of the New York Academy of Sciences·C ViticchiL Piantanelli
Jan 1, 1992·Archives of Gerontology and Geriatrics·A BassoL Piantanelli

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