Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats

Pharmacology, Biochemistry, and Behavior
Bart ScholtissenJos Prickaerts

Abstract

In Parkinson's disease (PD), several neurotransmitter systems, such as the dopaminergic and serotonergic system, show signs of degeneration. This led to the suggestion that alterations in the serotonergic system play a role in the pathophysiology of PD. Partial bilateral dopaminergic lesions of the caudate putamen complex (CPu) of rats induced by 6-hydroxydopamine (6-OHDA) produce behavioral symptoms mimicking PD. In the present study, the role of serotonin and dopamine was investigated both behaviorally and neuroanatomically. In a reaction time task, motor initiation and motor performance were impaired in the lesioned animals compared to controls. The performance of rats treated with d-amphetamine or serotonergic ligands (DOI and ketanserin) in the reaction time task indicated that 5-HT and DA appear to be agonistically related in the CPu. The relation was the same in both control and 6-OHDA lesioned rats. 12 weeks after lesioning, motor initiation recovered, whereas motor performance did not. Parallel to the behavioral study, a second group of animals was lesioned and, at 3 days, 6 weeks and 12 weeks after lesioning, a subgroup was killed to obtain a qualitative indication of the degree of 6-OHDA lesion. Over the three time p...Continue Reading

References

Dec 1, 1979·Psychiatry Research·H M van Praag, S de Haan
Sep 1, 1993·Trends in Neurosciences·B L Jacobs, C A Fornal
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·M L Wadenberg
Oct 1, 1996·The Journal of Clinical Psychiatry·R J Leo
Jan 1, 1996·Journal of Neural Transmission·W KuhnH Przuntek
Nov 11, 1998·Neuroscience and Biobehavioral Reviews·A Blokland
Mar 19, 1999·Journal of Neuroscience Research·N K NgP T Wong
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A Blokland, W Honig
May 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A D SmithM J Zigmond
Sep 17, 2003·Archives of Neurology·Levente KerenyiZsolt Szabo
Aug 18, 2004·Journal of Geriatric Psychiatry and Neurology·Albert F G Leentjens
May 5, 2005·The European Journal of Neuroscience·Alain CourtièreThierry Hasbroucq

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Citations

Jan 23, 2010·Neurotoxicity Research·Moritz Thede EckartRainer K -W Schwarting
Nov 2, 2007·Basic & Clinical Pharmacology & Toxicology·Tiina M KääriäinenPekka T Männistö
Feb 4, 2009·Neuroreport·Tiina M KääriäinenPekka T Männistö

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