Abstract
In Parkinson's disease (PD), several neurotransmitter systems, such as the dopaminergic and serotonergic system, show signs of degeneration. This led to the suggestion that alterations in the serotonergic system play a role in the pathophysiology of PD. Partial bilateral dopaminergic lesions of the caudate putamen complex (CPu) of rats induced by 6-hydroxydopamine (6-OHDA) produce behavioral symptoms mimicking PD. In the present study, the role of serotonin and dopamine was investigated both behaviorally and neuroanatomically. In a reaction time task, motor initiation and motor performance were impaired in the lesioned animals compared to controls. The performance of rats treated with d-amphetamine or serotonergic ligands (DOI and ketanserin) in the reaction time task indicated that 5-HT and DA appear to be agonistically related in the CPu. The relation was the same in both control and 6-OHDA lesioned rats. 12 weeks after lesioning, motor initiation recovered, whereas motor performance did not. Parallel to the behavioral study, a second group of animals was lesioned and, at 3 days, 6 weeks and 12 weeks after lesioning, a subgroup was killed to obtain a qualitative indication of the degree of 6-OHDA lesion. Over the three time p...Continue Reading
References
Dec 1, 1979·Psychiatry Research·H M van Praag, S de Haan
May 1, 1984·Neurology·R MayeuxJ B Williams
Sep 1, 1993·Trends in Neurosciences·B L Jacobs, C A Fornal
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·M L Wadenberg
Oct 1, 1996·The Journal of Clinical Psychiatry·R J Leo
Jan 1, 1996·Journal of Neural Transmission·W KuhnH Przuntek
Jan 1, 1997·Neuropsychobiology·R VolpiV Coiro
Aug 26, 1998·Experimental Neurology·D KirikA Björklund
Nov 11, 1998·Neuroscience and Biobehavioral Reviews·A Blokland
Mar 19, 1999·Journal of Neuroscience Research·N K NgP T Wong
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A Blokland, W Honig
Feb 28, 2001·Brain Research Bulletin·T Koskinen, J Sirviö
Mar 10, 2001·The Journal of Comparative Neurology·A RoedterG Nikkhah
May 15, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A D SmithM J Zigmond
Sep 17, 2003·Archives of Neurology·Levente KerenyiZsolt Szabo
Aug 18, 2004·Journal of Geriatric Psychiatry and Neurology·Albert F G Leentjens
Mar 16, 2005·Behavioural Pharmacology·A BloklandC Lieben
May 5, 2005·The European Journal of Neuroscience·Alain CourtièreThierry Hasbroucq
Citations
Jan 23, 2010·Neurotoxicity Research·Moritz Thede EckartRainer K -W Schwarting
Nov 17, 2009·Behavioural Brain Research·Igor BranchiEnrico Alleva
Jun 3, 2009·Brain, Behavior, and Immunity·Harald EnglerManfred Schedlowski
Nov 2, 2007·Basic & Clinical Pharmacology & Toxicology·Tiina M KääriäinenPekka T Männistö
Jun 22, 2013·The Journal of Comparative Neurology·Christoph LindemannKerstin Schwabe
Oct 29, 2009·Synapse·Yun LiQing Wang
Aug 8, 2006·Brain Research·Warren H Meck
Jan 31, 2013·Experimental Neurology·Andreas HeuerStephen B Dunnett
Dec 3, 2014·Neuroscience Research·Andrew L EagleHajime Otani
Feb 4, 2009·Neuroreport·Tiina M KääriäinenPekka T Männistö