PMID: 9526063Apr 4, 1998Paper

Functional involvement of benzodiazepine receptors in ethanol-induced increases of diazepam binding inhibitor (DBI) and its mRNA in the mouse brain

Brain Research. Molecular Brain Research
Masashi KatsuraK Kuriyama

Abstract

We have attempted to clarify the mechanisms for alcohol (EtOH)-induced elevation of diazepam binding inhibitor (DBI) mRNA and to investigate whether the increase in DBI mRNA is paralleled with that in DBI using EtOH-treated mice and primary cultured neurons. Both the DBI content and the expression of DBI mRNA were elevated in the cerebral cortex of EtOH-inhaled and -withdrawn mice. Simultaneous administration of flunitrazepam (FLN) and Ro15-1788 with EtOH vapor completely abolished the EtOH-induced elevation of DBI mRNA. In addition, the exposure of the neurons for 3 days significantly elevated the expression of DBI mRNA, which was completely inhibited by concomitant exposure of FLN, Ro15-4513 and Ro-15-1788 with EtOH, while muscimol and bicuculline showed no effects on the EtOH-induced increase of DBI mRNA expression. These results indicate that functional interaction between EtOH and benzodiazepine (BDZ) receptors is a critical role in the increased expression of DBI mRNA.

References

Jan 1, 1990·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·K Kuriyama, S Ohkuma
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Citations

Dec 26, 2001·Brain Research. Molecular Brain Research·M KatsuraS Ohkuma
Sep 5, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George R BreeseDavid H Overstreet
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·H SuwakiF Weiss
Oct 2, 2013·Biochimica Et Biophysica Acta·Maria BloksgaardSusanne Mandrup
Oct 3, 2007·Alcoholism, Clinical and Experimental Research·Darin J KnappGeorge R Breese
Apr 20, 2004·Brain Research. Molecular Brain Research·Masashi KatsuraSeitaro Ohkuma
Apr 23, 2015·Progress in Lipid Research·Ditte NeessNils J Færgeman
Apr 6, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·M Katsura
Dec 1, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Travis J Worst, Kent E Vrana
Oct 3, 2006·Molecular and Cellular Biochemistry·Nils J FaergemanJens Knudsen
May 20, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sung Won KimNora D Volkow

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