Functional link between phosphorylation state of membrane proteins and morphological changes of human erythrocytes

Biochemical and Biophysical Research Communications
Luciana BordinV Moret

Abstract

The Tyr-phosphorylation of the cytoplasmic domain of the major membrane-spanning band 3, rather than the Ser/Thr-phosphorylation of the membrane proteins (spectrin and band 3 itself), might be functionally related to certain morphological changes of human erythrocytes. This view is supported by the following lines of evidence: a) vanadate or its derivative pervanadate (vanadyl hydroperoxide), which markedly increase the Tyr-phosphorylation of band 3 (without practically affecting the Ser/Thr-phosphorylation of spectrin) promotes a crenation of human erythrocytes; b) okadaic acid, which selectively increases the Ser/Thr-phosphorylation of spectrin and other membrane proteins, does not promote any shape change, at least at a level detectable with scanning electron microscopy.

Citations

Jan 25, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Nadezhda N BarvitenkoRoy E Weber
Aug 22, 2008·The Journal of Chemical Physics·Rui Zhang, Frank L H Brown
Feb 6, 2015·The Journal of Membrane Biology·Pedro TeixeiraCarlota Saldanha
Apr 4, 2007·Annals of the New York Academy of Sciences·Marcantonio BragadinLuciana Bordin
Feb 1, 2006·Environmental Toxicology and Pharmacology·Luciana BordinGiulio Clari
May 29, 2015·Cell Death & Disease·T J LaRoccaA J Ratner
Mar 20, 2014·Free Radical Biology & Medicine·Mattia ZaccarinStefano Toppo
Aug 9, 2005·Biochimica Et Biophysica Acta·Luciana BordinPhilip S Low
May 16, 2006·Biochimica Et Biophysica Acta·Luciana BordinGiulio Clari
Sep 29, 2005·Pediatric Research·Barbara MarzocchiGiuseppe Buonocore
Nov 26, 2005·Molecular Membrane Biology·Luciana BordinGiulio Clari
Jun 19, 2018·Frontiers in Physiology·Rick HuisjesRichard van Wijk
Jul 2, 1998·Biochemical and Biophysical Research Communications·F CarbonnetO Bertrand
Jul 9, 2002·Biochimica Et Biophysica Acta·Antonio GaltieriIrene Messana
Sep 10, 2008·Archives of Biochemistry and Biophysics·Cristina FioreGiulio Clari

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