Functional magnetic resonance imaging of the primary somatosensory cortex in piglets

Journal of Neurosurgery
A C DuhaimePaul Tomashosky

Abstract

The piglet is an excellent model for the developing human brain, and has been used increasingly in various centers for studies of traumatic brain injury and other insults. Unlike rodent or primate models, however, there are few behavioral scales for the piglet, and the available ones are used to test general responsiveness rather than specific functional outcome. The differing behavioral repertoires of animals of different ages provide an additional challenge when age-dependent injury responses are compared. To overcome these experimental limitations of piglets in brain injury research, the authors developed a functional magnetic resonance (fMR) imaging paradigm that can be used to track recovery in the somatosensory cortex over time in anesthetized animals of different ages. Fifteen fMR imaging studies in eight piglets were performed before and after scaled cortical impact injury to the primary somatosensory cortex subserving snout sensation. Specific anesthetic and imaging protocols enabled visualization of cortical activation, and comparison with somatosensory evoked potentials obtained before and after injury was obtained. A piglet brain template for group-level analysis of these data was constructed, similar to the fMR ima...Continue Reading

References

Dec 1, 1989·Journal of Pediatric Psychology·L Ewing-CobbsH S Levin
Mar 18, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M LahtiJ A King
Apr 22, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Y OkadaC Xu
Aug 10, 1999·Journal of the International Neuropsychological Society : JINS·A J SaykinJ B Weaver
Sep 2, 2000·Journal of Neurosurgery·A C DuhaimeR Raghupathi
Aug 2, 2001·The Journal of Thoracic and Cardiovascular Surgery·T SakamotoR A Jonas
Feb 16, 2002·Topics in Magnetic Resonance Imaging : TMRI·Russell A PoldrackP Ellen Grant
Mar 13, 2002·Experimental Brain Research·David A LeopoldNikos K Logothetis
Mar 22, 2002·Veterinary Ophthalmology·C K WillisD Nicolle
Sep 10, 2003·Journal of Neurosurgery·Ann-Christine DuhaimeChristine Harris
May 14, 2004·Brain : a Journal of Neurology·Andrew J SaykinRobert B Santulli

❮ Previous
Next ❯

Citations

Aug 1, 2009·Animal : an International Journal of Animal Bioscience·P SauleauC-H Malbert
Jan 26, 2016·Journal of Agricultural and Food Chemistry·Marlon M ReisNicole Roy
May 30, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Andrew O KoobAnn-Christine Duhaime
Sep 1, 2006·Developmental Neuroscience·Ann-Christine Duhaime

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
imaging techniques
imaging technique

Software Mentioned

house
SPM99
MATLAB

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.