Functional mapping in the corpus callosum: a 4T fMRI study of white matter

NeuroImage
Jodie R GawrylukSteven D Beyea

Abstract

The idea of fMRI activation in white matter (WM) is controversial. Our recent work has used two different approaches to investigate whether there is evidence for WM fMRI. The first approach used words and faces to elicit interhemispheric transfer activation in the posterior corpus callosum (Sperry task). The second approach used checkerboard stimuli to elicit similar activation in the anterior corpus callosum (Poffenberger task). Using these different tasks, it has been possible to detect WM activation in different regions. In the current study, we report the results of a critical experiment: demonstrating that callosal activation can be experimentally manipulated within the same set of individuals. All subjects completed both the Sperry and Poffenberger tasks. Functional MRI data were acquired at 4T, using an asymmetric spin echo spiral sequence. Data were analyzed with FSL using a model-based approach. Analyses focused on group and individual activations in WM. Corpus callosum activation was elicited for both tasks, with activation varying according to task type. A statistical contrast of the two tasks revealed posterior callosal activation for the Sperry task and anterior callosal activation for the Poffenberger task. The Sp...Continue Reading

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Citations

Jul 17, 2013·Experimental Brain Research·Vincenzo FlorioCarlo A Marzi
Apr 21, 2011·Neuroinformatics·Wieslaw L NowinskiGuo Yu Qian
Jun 16, 2011·BMC Neuroscience·Jodie R GawrylukRyan C N D'Arcy
Mar 16, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Giovanni Berlucchi
Jun 30, 2012·Journal of Neuroscience Methods·Sean R McWhinneyRyan C N D'Arcy
Jun 15, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Giovanni Berlucchi
Aug 13, 2013·BioMed Research International·Pengxu Wei, Ruixue Bao
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Mar 13, 2012·NeuroImage·Umesh S RudrapatnaRick M Dijkhuizen
Aug 20, 2014·Frontiers in Human Neuroscience·Jodie R GawrylukRyan C N D'Arcy
Sep 26, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaoling WangKathleen K S Hui
Nov 11, 2018·Human Brain Mapping·Gong-Jun JiKai Wang
Mar 14, 2013·PloS One·Erin L MazerolleRyan C N D'Arcy
Oct 23, 2019·Frontiers in Neuroscience·Lukas A GrajauskasRyan C N D'Arcy
Oct 22, 2019·Frontiers in Neurology·Péter FaragóZsigmond Tamás Kincses
Mar 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Xiao WangHuafu Chen
Apr 25, 2020·NeuroImage·Arabinda MishraJohn C Gore
Oct 31, 2021·Proceedings of the National Academy of Sciences of the United States of America·Muwei LiJohn C Gore
Nov 24, 2021·Brain Structure & Function·Tory O FrizzellRyan C N D'Arcy

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