Functional mapping of quantitative trait loci underlying growth trajectories using a transform-both-sides logistic model

Biometrics
Rongling WuGeorge Casella

Abstract

The incorporation of developmental control mechanisms of growth has proven to be a powerful tool in mapping quantitative trait loci (QTL) underlying growth trajectories. A theoretical framework for implementing a QTL mapping strategy with growth laws has been established. This framework can be generalized to an arbitrary number of time points, where growth is measured, and becomes computationally more tractable, when the assumption of variance stationarity is made. In practice, however, this assumption is likely to be violated for age-specific growth traits due to a scale effect. In this article, we present a new statistical model for mapping growth QTL, which also addresses the problem of variance stationarity, by using a transform-both-sides (TBS) model advocated by Carroll and Ruppert (1984, Journal of the American Statistical Association 79, 321-328). The TBS-based model for mapping growth QTL cannot only maintain the original biological properties of a growth model, but also can increase the accuracy and precision of parameter estimation and the power to detect a QTL responsible for growth differentiation. Using the TBS-based model, we successfully map a QTL governing growth trajectories to a linkage group in an example of...Continue Reading

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Citations

May 17, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Runqing YangXiaojing Zhou
Aug 18, 2009·Journal of Mathematical Biology·Jiangtao LuoRongling Wu
Mar 4, 2010·Genetics Research·Tianbo JinRongling Wu
May 26, 2012·Genetics Research·Jun XingShizhong Xu
Mar 24, 2010·Journal of Biopharmaceutical Statistics·Min LinRongling Wu
Mar 17, 2005·Bioinformatics·Wei ZhaoRongling Wu
Mar 30, 2007·Bioinformatics·Min LinRongling Wu
Nov 26, 2009·Biological Reviews of the Cambridge Philosophical Society·Yao Li, Rongling Wu
Jun 12, 2012·International Journal of Plant Genomics·Kiranmoy DasRongling Wu
Mar 19, 2008·Theoretical Biology & Medical Modelling·Yuehua CuiGengxin Li
Apr 18, 2008·Theoretical Biology & Medical Modelling·Kiranmoy Das, Rongling Wu
Sep 17, 2004·Genetics·Rongling WuJames M Cheverud
Oct 6, 2009·Statistical Applications in Genetics and Molecular Biology·Yao LiRongling Wu
Mar 26, 2013·Advanced Drug Delivery Reviews·Zhong WangRongling Wu
Apr 2, 2013·Briefings in Bioinformatics·Zhongwen HuangRongling Wu
Nov 19, 2004·Journal of Mathematical Biology·Tian LiuRongling Wu
May 22, 2010·Trends in Pharmacological Sciences·Kwangmi AhnRongling Wu
Jul 28, 2009·Journal of Theoretical Biology·Ning LiRongling Wu
Jun 10, 2008·Biometrics·Jie YangGeorge Casella
Apr 12, 2016·BioMed Research International·Jiandong QiJianxin Wang
Jan 15, 2011·Molecular Microbiology·Javier ArroyoSabine Strahl
Feb 9, 2012·Genetic Epidemiology·Shuang WangFrederica P Perera
May 3, 2006·Journal of Theoretical Biology·Hongying LiRongling Wu
Dec 9, 2008·BMC Genetics·Zhigang Guo, James C Nelson
Jul 3, 2010·Theoretical Biology & Medical Modelling·Guifang FuRongling Wu
Aug 1, 2014·Briefings in Bioinformatics·Meixia YeRongling Wu
Jul 21, 2010·PloS One·Chenguang WangRongling Wu

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