Functional mechanisms for type 2 diabetes-associated genetic variants

Journal of Diabetes and Its Complications
Xiao-Wei ZhuShu-Feng Lei

Abstract

Type 2 diabetes (T2D) is a complex endocrine and metabolic disorder, characterized by hyperglycemia due to insulin resistance and relative lack of insulin. Several recent studies have identified a large number of genetic loci associated with T2D without exploring functional mechanisms underlying the associations. This study established integrative analyses to detect the functional mechanisms for T2D-related associations. Based on the public available datasets and resources, this study performed integrative analyses (gene relationships among implicated loci (GRAIL), expression quantitative trait loci (eQTL) analysis, differential gene expression analysis and functional prediction analysis) to detect the molecular functional mechanisms underlying the associations. Two single nucleotide polymorphisms (SNPs) (rs7593730, rs2439312) have been found to act as cis-effect regulators of two corresponding eQTL genes (RBMS1, NRG1) among 252 selected (P<E-4) genetic associations that were archived in the public databases. These two non-HLA genes were also differentially expressed in T2D-related cell groups. The two SNPs were predicted as regulatory sites by utilizing online prediction tools. This study detected potential regulatory mechanis...Continue Reading

References

Sep 18, 2007·Nature Genetics·Barbara E StrangerEmmanouil T Dermitzakis
Nov 6, 2007·Nature Genetics·Amanda J MyersJohn Hardy
May 9, 2008·PLoS Biology·Eric E SchadtRoger Ulrich
Oct 11, 2008·PLoS Genetics·Jean-Baptiste VeyrierasJonathan K Pritchard
Aug 1, 2009·Science·Antigone S DimasStylianos E Antonarakis
Nov 17, 2009·Stroke; a Journal of Cerebral Circulation·Hu DingDao Wen Wang
Apr 27, 2010·Human Molecular Genetics·Lu QiUNKNOWN Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium
Jun 29, 2010·Trends in Pharmacological Sciences·Caline S KaramJonathan A Javitch
Apr 26, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bo PanChao Deng
May 7, 2011·American Journal of Nephrology·Mariana MureaBarry I Freedman
May 17, 2011·European Psychiatry : the Journal of the Association of European Psychiatrists·D SchoepfR Heun
Jan 31, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Chun GuiQicheng Long
Feb 2, 2012·Genome Biology·Daniel J GaffneyJonathan K Pritchard
Aug 21, 2013·World Journal of Diabetes·Omar Ali

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