Functional Mesoporous Silica Nanocomposites: Biomedical applications and Biosafety

International Journal of Molecular Sciences
Rafael R Castillo, María Vallet-Regí

Abstract

The rise and development of nanotechnology has enabled the creation of a wide number of systems with new and advantageous features to treat cancer. However, in many cases, the lone application of these new nanotherapeutics has proven not to be enough to achieve acceptable therapeutic efficacies. Hence, to avoid these limitations, the scientific community has embarked on the development of single formulations capable of combining functionalities. Among all possible components, silica-either solid or mesoporous-has become of importance as connecting and coating material for these new-generation therapeutic nanodevices. In the present review, the most recent examples of fully inorganic silica-based functional composites are visited, paying particular attention to those with potential biomedical applicability. Additionally, some highlights will be given with respect to their possible biosafety issues based on their chemical composition.

References

Feb 6, 2007·Angewandte Chemie·An-Hui LuFerdi Schüth
Aug 4, 2007·Lasers in Medical Science·Xiaohua HuangMostafa A El-Sayed
Sep 15, 2007·Angewandte Chemie·María Vallet-RegíDaniel Arcos
Jul 9, 2008·Nature Medicine·Hakho LeeRalph Weissleder
Feb 24, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hikaru NishimoriKiyohito Yagi
Feb 26, 2009·Chemical Communications : Chem Comm·Fabio CarniatoMauro Botta
Feb 27, 2009·Annals of Biomedical Engineering·Xiaoge HuXiaohu Gao
May 8, 2009·Chemical Society Reviews·Feng Wang, Xiaogang Liu
Dec 1, 2007·Biointerphases·Cristina BuzeaKevin Robbie
Oct 15, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Zaki G EstephanJoseph B Schlenoff
Nov 3, 2010·International Journal of Oncology·Stephan HackenbergNorbert Kleinsasser
Jan 5, 2012·Chemical Society Reviews·Zongxi LiJeffrey I Zink
Mar 2, 2012·Advanced Materials·Fangqiong TangDong Chen
Oct 6, 2012·Advanced Drug Delivery Reviews·Theresa M Allen, Pieter R Cullis
Jul 3, 2013·Chemistry of Materials : a Publication of the American Chemical Society·Katie R HurleyChristy L Haynes
Sep 17, 2013·Analytical and Bioanalytical Chemistry·Lijun XieGangfeng Ouyang
Oct 22, 2013·Drug Discovery Today·Abhalaxmi Singh, Sanjeeb K Sahoo
Feb 5, 2014·Journal of Nanobiotechnology·Li ShangGerd Ulrich Nienhaus
Feb 20, 2014·AAPS PharmSciTech·Burapol SinghanaMarites P Melancon
Jul 18, 2014·Nanoscale·D JaqueJ García Solé
Sep 2, 2014·Chemical Society Reviews·Anna GnachJohn A Capobianco
Oct 16, 2014·Chemical Society Reviews·Shi Ying LimZhiqiang Gao
Oct 31, 2014·Science Translational Medicine·Evan PhillipsMichelle S Bradbury
Mar 1, 2011·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Stefaan J SoenenMarcel De Cuyper
Nov 26, 2014·Expert Opinion on Drug Delivery·Alejandro BaezaMaría Vallet-Regí
Dec 3, 2014·ACS Applied Materials & Interfaces·Arjyabaran SinhaNikhil R Jana

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Citations

Mar 23, 2019·Expert Opinion on Drug Delivery·Rafael R CastilloMaría Vallet-Regí
Dec 6, 2019·Frontiers in Bioengineering and Biotechnology·Yu YangXinxin Li
May 13, 2020·Pharmaceutics·Rafael R CastilloMaría Vallet-Regí
Jun 21, 2019·International Journal of Molecular Sciences·Lara GiussaniEttore Fois
Oct 3, 2020·Sensors·Ruth Prieto-MonteroVirginia Martínez-Martínez
Jul 28, 2020·Frontiers in Immunology·Anna I JoubertMartin Himly
Oct 21, 2020·Biotechnology Journal·Rafael R Castillo, Maria Vallet-Regí
Jan 25, 2021·Analytica Chimica Acta·Luis PlaSara Santiago-Felipe
Oct 30, 2020·International Journal of Molecular Sciences·Rafael R CastilloMaría Vallet-Regí
Feb 13, 2021·Chemistry : a European Journal·Viktoriya Sokolova, Matthias Epple
Mar 30, 2021·Bio-medical Materials and Engineering·Mario Pérez SayansPía López Jornet
Jun 11, 2021·Journal of Agricultural and Food Chemistry·Xiang-Ping KongJuan Wang
Jul 9, 2021·International Journal of Nanomedicine·Rafael R Castillo, María Vallet-Regí
Jul 16, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alba García-FernándezRamón Martínez-Máñez
Sep 4, 2021·Beilstein Journal of Nanotechnology·Sepand Tehrani FatehAmin Shiralizadeh Dezfuli

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Methods Mentioned

BETA
transfection
xenografts
Fluorescence
Fluorescence imaging
xenograft
X-ray

Clinical Trials Mentioned

NCT01679470
NCT01266096

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