Functional Mitochondria Are Important for the Effect of Resveratrol

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Anne L WidlundOle Vang

Abstract

Resveratrol (Resv) is a polyphenol reported to modulate mitochondrial activity. The aim was to use HeLa and 143B cells to characterize the action of Resv on mitochondrial activity, cell size and proliferation using wild type (WT) and Rho 0 cells deficient in mitochondrial DNA. In both HeLa WT and Rho 0 cells, the oxygen consumption rate (OCR) was increased at 20 µM Resv after 24 h, whereas only a non-significant increase of OCR was observed in 143B WT cells. Resv decreased cell number concentration-dependently in both WT and Rho 0 cell types. An increased cell diameter was observed in HeLa WT, but not in Rho 0 when treated with Resv. Overall, the findings presented indicate that functional mitochondria are a prerequisite for cell enlargement by Resv.

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Citations

Oct 14, 2017·Nutrients·Corina T Madreiter-SokolowskiWolfgang F Graier
Oct 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dominique Vervandier-FasseurNorbert Latruffe
Feb 8, 2019·Cell Death Discovery·Irina I SuvorovaValery A Pospelov
Jun 18, 2020·Foods·Nikola GligorijevićTanja Ćirković Veličković

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Methods Mentioned

BETA
flow cytometry
PCR

Software Mentioned

GraphPad Prism
BD [UNK] Pro Analysis
Evolva

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