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Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells

Stem Cells and Development

May 6, 2011

Anyou WangGuoping Fan

Abstract

It has been debated whether human induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) express distinctive transcriptomes. By using the method of weighted gene co-expression network analysis, we showed here that iPSCs exhibit altered functional modules compared with ES...read more

Mentioned in this Paper

Metabolic Process, Cellular
Support Vector Machines
Immune Response
DNA Methylation [PE]
Pluripotent Stem Cells
Genes
Transcription, Genetic
Enhanced S-Cone Syndrome
Human Induced Pluripotent Stem Cells
DNA Methylation
Paper Details
References
  • References52
  • Citations20
12

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Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells

Stem Cells and Development

May 6, 2011

Anyou WangGuoping Fan

PMID: 21542696

DOI: 10.1089/scd.2010.0574

Abstract

It has been debated whether human induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) express distinctive transcriptomes. By using the method of weighted gene co-expression network analysis, we showed here that iPSCs exhibit altered functional modules compared with ES...read more

Mentioned in this Paper

Metabolic Process, Cellular
Support Vector Machines
Immune Response
DNA Methylation [PE]
Pluripotent Stem Cells
Genes
Transcription, Genetic
Enhanced S-Cone Syndrome
Human Induced Pluripotent Stem Cells
DNA Methylation

Similar Papers Found In These Feeds

Epigenetic Clocks (Keystone)

Aging is associated with reproducible changes in DNA methylation, and this epigenetic aging signature can be used to predict biological age. Find the latest research on epigenetic clocks here.

DNA Methylation

DNA methylation is an epigenetic mechanism of gene regulation, and dysregulation of DNA methylation has been associated with tumorigenesis. Discover the latest research on DNA methylation here.

Related Papers

Current Opinion in Genetics & Development

Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?

Current Opinion in Genetics & DevelopmentOctober 20, 2012
William E Lowry
Paper Details
References
  • References52
  • Citations20
12
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