Functional monoamine oxidase B gene intron 13 polymorphism predicts putaminal dopamine turnover in de novo Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Matthias LöhleAlexander Storch

Abstract

The objective of this study was to evaluate the effects of common functional polymorphisms in genes involved in dopamine metabolism on striatal dopamine turnover in de novo Parkinson's disease (PD). This was an observer-blinded cohort study investigating effects of common functional polymorphisms in dopa decarboxylase (DDC, rs921451), monoamine oxidase B (MAOB; rs1799836), catechol-O-methyltransferase (COMT, rs4680), and dopamine transporter/solute carrier family 6 member 3 (DAT/SLC6A3, variable number tandem repeats) genes on 18 F-fluorodopa uptake and an effective distribution volume ratio (inverse of dopamine turnover) measured by 18 F-fluorodopa PET in 28 untreated PD patients. Patients carrying the MAOBCC/(C)/CT genotype (low/intermediate enzyme activity) had a lower dopamine turnover in the putamen (higher mean effective distribution volume ratio) when compared with patients with MAOBTT/(T) genotype (high enzyme activity). Striatal PET measures were not different between variants in the remaining genes. The MAOB (rs1799836) polymorphism predicts putaminal dopamine turnover in early PD with the MAOBTT allele linked to high enzyme activity leading to higher intrinsic dopamine turnover, which has been demonstrated to constit...Continue Reading

References

Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Apr 1, 1991·Archives of Neurology·D B Calne, M J Zigmond
May 1, 1967·Neurology·M M Hoehn, M D Yahr
Mar 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S PatlakJ D Fenstermacher
Jan 29, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·A HeinzD R Weinberger
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V SossiJ E Holden
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vesna SossiT J Ruth
Mar 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V SossiA J Stoessl
Feb 13, 2004·Brain : a Journal of Neurology·Raúl de la Fuente-FernándezA Jon Stoessl
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Vesna SossiJon Stoessl
Feb 16, 2006·Brain : a Journal of Neurology·Vesna SossiJon Stoessl
Oct 13, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Vesna SossiJon A Stoessl
Nov 13, 2013·Parkinsonism & Related Disorders·David DevosJean-Christophe Corvol
Mar 1, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul EisenbergKaren F Berman

❮ Previous
Next ❯

Citations

Dec 22, 2019·Journal of Neural Transmission·Matthias LöhleAlexander Storch
Oct 15, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S JesúsP Mir
Apr 10, 2021·Journal of Chemical Neuroanatomy·Danielle N Jones, Mary Ann Raghanti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.