PMID: 11906659Mar 22, 2002Paper

Functional MRI as a tool to assess vision in dogs: the optimal anesthetic

Veterinary Ophthalmology
C K WillisD Nicolle

Abstract

Functional magnetic resonance imaging (fMRI) is a recent advance in neuroimaging that provides a picture of brain activity with excellent spatial resolution. Current methods used to evaluate canine vision are poorly standardized and vulnerable to bias. Functional MRI may represent a valuable method of testing vision in dogs if the impacts of anesthesia on fMRI are understood. Six dogs were scanned during visual stimulation, each under three different anesthetic protocols (isoflurane, propofol, fentanyl/midazolam) to address the questions: (1) Can visually evoked fMR signals be reliably recorded in anesthetized dogs? and (2) Which anesthetic agent permits the least suppression of visually induced fMR signal in dogs? This study confirms that visual stimuli reliably elicit neural activity and fMR signal change in anesthetized dogs. No significant differences in images acquired under the three anesthetics were found, and there was no significant relationship between anesthetic dose and brain activity, within the range of doses used in this study. Images obtained during isoflurane anesthesia were more consistent between dogs than those obtained with the other two agents. This reduced variation may reflect the fact that inhalant anes...Continue Reading

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Citations

Nov 26, 2003·Epilepsia·Zhao GongEdward J Kendall
Oct 18, 2013·BMC Veterinary Research·Jan-Peter BachIngo Nolte
May 19, 2012·PloS One·Gregory S BernsMark Spivak
Jan 4, 2013·PloS One·Ritobrato DattaGeoffrey K Aguirre
Dec 11, 2013·PloS One·Gregory S BernsMark Spivak
Jan 2, 2010·American Journal of Veterinary Research·Monique M GarciaAndrás M Komáromy
Mar 29, 2012·American Journal of Veterinary Research·Ron OfriChristopher J Murphy
Apr 20, 2006·Journal of Neurosurgery·Ann-Christine DuhaimePaul Tomashosky
Nov 27, 2018·The Journal of Small Animal Practice·K L GrahamA White
Apr 18, 2020·PloS One·Katrin M BeckmannSven Haller
Jul 12, 2002·NMR in Biomedicine

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