Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates

The European Journal of Neuroscience
Michael CzischDorothee P Auer

Abstract

Prominent local decreases in blood oxygenation level (BOLD) can be observed by functional magnetic resonance imaging (fMRI) upon acoustic stimulation during sleep. The goal of this study was to further characterize this BOLD signal decrease with respect to corresponding neurophysiological phenomena using a simultaneous electroencephalography (EEG)/fMRI approach in sleeping human subjects. Healthy volunteers were subjected to acoustic stimulation during non-rapid eye movement (NREM) sleep. On the basis of statistical parametric maps, the correlations between the fMRI response (both amplitude and extent of the BOLD response) and the concomittant changes in the EEG (delta power and K-complexes) were calculated. Amplitude and extent of the stimulus-induced negative BOLD effect correlated positively with measures of EEG synchronization, namely an increase in the number of K-complexes and EEG delta power. Stimulus-induced BOLD decreases were most prominent during light (stage 2) NREM sleep and disappeared during slow wave sleep, indicating an influence of the baseline degree of hyperpolarization. Our observations provide first evidence that 'negative' BOLD signal changes during human sleep are associated with electrophysiological ind...Continue Reading

References

Mar 1, 1995·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·H BastujiF Mauguière
Jul 1, 1997·Brain : a Journal of Neurology·A R BraunP Herscovitch
Mar 1, 1995·NeuroImage·K J FristonR Turner
Dec 24, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L LemieuxD R Fish
Jul 15, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J L AnderssonB Långström
Sep 29, 1998·Electroencephalography and Clinical Neurophysiology·F Amzica, M Steriade
Jan 23, 1999·Neurophysiologie clinique = Clinical neurophysiology·P Halász
Jun 1, 1994·Journal of Sleep Research·C Bastien, K Campbell
Sep 1, 1995·Journal of Sleep Research·A WauquierA Declerck
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A HoffmannM Reiser
Dec 20, 2000·Brain Research·T J Sejnowski, A Destexhe
Feb 24, 2001·Canadian Journal of Experimental Psychology = Revue Canadienne De Psychologie Expérimentale·K B Campbell
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
Jul 17, 2001·The European Journal of Neuroscience·L A FinelliP Achermann
Oct 5, 2001·Nature Reviews. Neuroscience·D A GusnardM E Raichle
Feb 12, 2002·Nature Reviews. Neuroscience·David J Heeger, David Ress
May 30, 2002·Magnetic Resonance Imaging·A P BornH C Lou
Jul 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Fahmeed HyderRobert G Shulman
Aug 13, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Noam HarelSeong-Gi Kim
Sep 11, 2002·Journal of Sleep Research·Troels W KjaerPeter L Madsen
Nov 5, 2002·NeuroImage·Alfred Peter BornOlaf B Paulson
Jan 18, 2003·Sleep Medicine Reviews·Florin Amzica, Mircea Steriade
Nov 6, 2003·Human Brain Mapping·Adriaan Moelker, Peter M T Pattynama
Aug 18, 2004·Sleep Medicine Reviews·H Bastuji, L García-Larrea

❮ Previous
Next ❯

Citations

Aug 9, 2005·Experimental Brain Research·Valerie WeisserK Sathian
Jun 25, 2013·Brain Topography·Francesca PittauJean Gotman
Jan 26, 2012·Neuromolecular Medicine·Thien Thanh Dang-Vu
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thien Thanh Dang-VuPierre Maquet
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Enzo TagliazucchiHelmut Laufs
Feb 19, 2011·Cerebral Cortex·Philipp G SämannMichael Czisch
Sep 7, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Victor I SpoormakerLutz Jäncke
Oct 6, 2007·Epilepsia·Bart P Keogh, Dietmar Cordes
Sep 15, 2005·PLoS Medicine·Alexander DrzezgaAlexander Kurz
Aug 27, 2009·PloS One·Michael CzischPhilipp G Sämann
Oct 27, 2009·PloS One·Danilo MenicucciAngelo Gemignani
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elias B Issa, Xiaoqin Wang
Nov 6, 2013·Pharmacology & Therapeutics·M DreslerF Holsboer
Oct 2, 2013·Sleep·Derrick J PhillipsDavid M Rector
Mar 23, 2012·Sleep Medicine·Alessandra Del FelicePaolo Manganotti
Jul 29, 2008·Neuroscience Letters·Jan MoehringMichael Siniatchkin
Apr 28, 2007·Magnetic Resonance Imaging·Petra RitterArno Villringer
Dec 21, 2006·Neurobiology of Learning and Memory·Elizabeth HennevinJean-Marc Edeline
Dec 21, 2005·Journal of Sleep Research·Mario Giovanni TerzanoFranco Ferrillo
Nov 16, 2011·Human Brain Mapping·Umair J ChaudharyLouis Lemieux
Jan 23, 2010·The European Journal of Neuroscience·Nikolai AxmacherJuergen Fell
Jun 10, 2009·Human Brain Mapping·Louise TyvaertJean Gotman
Feb 18, 2005·Sleep Medicine·P HalászL Parrino
Aug 17, 2006·Neuroscience and Biobehavioral Reviews·Petra Ritter, Arno Villringer
Jun 3, 2006·Sleep Medicine·Mario Giovanni TerzanoLiborio Parrino
Apr 21, 2006·NeuroImage·Khalid HamandiLouis Lemieux
Jan 24, 2006·NeuroImage·Tali GorfineNava Zisapel
Oct 26, 2005·NeuroImage·Laura M ParkesDavid G Norris
Nov 12, 2013·Trends in Neurosciences·Lisa GenzelFrancesco P Battaglia

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