Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia

Stroke; a Journal of Cerebral Circulation
Young R KimEng H Lo

Abstract

The use of lithium as a neuroprotective agent has been demonstrated using various models in which improvements in infarct size, DNA damage, and neurological function were reported. We further investigated neurohemodynamic aspects of the treatment-associated recovery by assessing the therapeutic efficacy of delayed chronic lithium treatment using functional MRI. Ipsilesional functional MRI activations in the somatosensory cortex, acquired 2 weeks after the 90-minute transient middle cerebral artery occlusion, were compared between lithium- and saline-treated rats. Specifically, MRI signal changes based on blood oxygenation level dependence and functional cerebral blood volume responses were examined using electrical stimulation of forelimbs. Additional immunohistochemical assays were performed. The ratio of ipsilesional to contralesional blood oxygenation level dependence response magnitudes significantly improved with lithium treatments. In contrast, the increase of the functional cerebral blood volume response magnitude ratio was not statistically significant. Nonetheless, the lithium treatment induced significant enhancements of total functional MRI activation (defined as a product of activation volume and response magnitude)...Continue Reading

References

May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Apr 16, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleR M Weisskoff
Dec 5, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J DennieR M Weisskoff
Nov 5, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B MandevilleB R Rosen
Sep 20, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G ZaharchukB R Rosen
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·R V BhatC M Lee
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·D Le BihanH Chabriat
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·R M DijkhuizenS P Finklestein
Jun 20, 2002·Bipolar Disorders·De-Maw ChuangPeter Leeds
Aug 9, 2002·The Journal of Biological Chemistry·Hyo-Soo KimKenneth Walsh
Apr 5, 2003·Stroke; a Journal of Cerebral Circulation·Jihong XuPeter Gohlke
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ming RenDe-Maw Chuang
Jun 11, 2004·Journal of Neurochemistry·Ratan V BhatJesús Avila
Oct 19, 2004·Expert Reviews in Molecular Medicine·Michael K Rowe, De-Maw Chuang
Mar 11, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Young R KimBruce R Rosen
Mar 28, 2006·Nature Medicine·Bing-Qiao ZhaoEng H Lo
Dec 7, 2006·The Journal of Biological Chemistry·Min-Huei Liang, De-Maw Chuang

❮ Previous
Next ❯

Citations

Nov 19, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Won-Jung ShinPyung-Hwan Park
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Nov 1, 2008·Stroke; a Journal of Cerebral Circulation·Shuzhen GuoEng H Lo
Feb 13, 2010·Journal of Angiogenesis Research·Stefan Liebner, Karl H Plate
Apr 23, 2014·PloS One·Ludwig F ZeilbeckAndreas Ohlmann
Jun 6, 2013·Neural Plasticity·Lin JiangChunshui Yu
Mar 13, 2012·Translational Stroke Research·Rick M DijkhuizenMaurits P A van Meer
Sep 17, 2011·Canadian Journal of Physiology and Pharmacology·R Wix-Ramos, A Eblen-Zajjur
Dec 8, 2015·Critical Reviews in Oncology/hematology·Mohammad Ali SaghiriNader Sheibani
Jul 17, 2013·Current Opinion in Pharmacology·Elisabeth JonckersMarleen Verhoye
Apr 5, 2014·ACS Chemical Neuroscience·Peter R LeedsDe-Maw Chuang
Feb 19, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J Y SuhYoung R Kim
Nov 6, 2009·CNS Neuroscience & Therapeutics·Antoni CaminsMercé Pallás
Feb 19, 2014·Pharmacology, Biochemistry, and Behavior·Adem CanTodd D Gould
May 12, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A V ProninO A Gromovа

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.