Functional MRI of Handwriting Tasks: A Study of Healthy Young Adults Interacting with a Novel Touch-Sensitive Tablet

Frontiers in Human Neuroscience
Mahta KarimpoorSimon J Graham

Abstract

Handwriting is a complex human activity that engages a blend of cognitive and visual motor skills. Current understanding of the neural correlates of handwriting has largely come from lesion studies of patients with impaired handwriting. Task-based fMRI studies would be useful to supplement this work. To address concerns over ecological validity, previously we developed a fMRI-compatible, computerized tablet system for writing and drawing including visual feedback of hand position and an augmented reality display. The purpose of the present work is to use the tablet system in proof-of-concept to characterize brain activity associated with clinically relevant handwriting tasks, originally developed to characterize handwriting impairments in Alzheimer's disease patients. As a prelude to undertaking fMRI studies of patients, imaging was performed of twelve young healthy subjects who copied sentences, phone numbers, and grocery lists using the fMRI-compatible tablet. Activation maps for all handwriting tasks consisted of a distributed network of regions in reasonable agreement with previous studies of handwriting performance. In addition, differences in brain activity were observed between the test subcomponents consistent with diff...Continue Reading

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Citations

Feb 25, 2020·Human Brain Mapping·Yang YangZhentao Zuo
May 7, 2019·Frontiers in Human Neuroscience·Ivy D DengSimon J Graham
Jun 10, 2021·Neurocase·Shahryar ZainaeeDavood Sobhani-Rad
Jul 7, 2021·Brain Structure & Function·Junjun LiYang Yang

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Methods Mentioned

BETA
PCA
SMA

Software Mentioned

Analysis of Functional NeuroImages freeware ( AFNI )
Psychology
prime
OPPNI
3dDetrend
3dmerge
3dretroicor
3dvolreg
MATLAB
3dTshift

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