Functional MRI study of a serial reaction time task in Huntington's disease

Psychiatry Research
Jin-Suh KimG D Pearlson

Abstract

The aim of this study was to investigate pathophysiological changes at an early stage of clinical Huntington's disease (HD) using a functional magnetic resonance imaging (fMRI) study and a serial reaction time task paradigm. Mildly affected and presymptomatic HD subjects (n = 8) and healthy normal controls (NC, n = 12) were studied. A group behavioral effect of implicit learning was seen only in the control population. Individual statistical parametric mapping (SPM) analysis showed more consistent activation of the caudate nucleus and putamen in the NC group. In the HD group, the group average SPM showed significant activation in the right head of caudate nucleus, as well as bilateral thalami, left middle temporal, right superior temporal, right superior frontal, right middle and inferior frontal and right postcentral gyri. In the comparison of between-group differences (NC-HD), reduced activation in the HD group relative to NC was observed in the right middle frontal, left middle occipital, left precuneus, and left middle frontal gyri. The variable striatal activity in the Huntington's group suggests early functional loss possibly associated with previously demonstrated early atrophy of these same neural structures.

References

Dec 1, 1996·Archives of Neurology·E H AylwardJ Brandt
Sep 1, 1995·NeuroImage·K J Worsley, K J Friston
Jan 27, 1998·The Psychiatric Clinics of North America·S L Rauch, C R Savage
Oct 24, 2001·Brain : a Journal of Neurology·R G BrownS Channon
Apr 26, 2002·Neuroreport·Vincent P ClarkA Wallace Deckel

❮ Previous
Next ❯

Citations

Sep 1, 2005·Current Neurology and Neuroscience Reports·Julie C Stout, Shannon A Johnson
May 31, 2012·Journal of the International Neuropsychological Society : JINS·Marieke van AsselenMiguel Castelo-Branco
Oct 19, 2011·Brain Research Bulletin·Simon P BrooksStephen B Dunnett
May 12, 2009·Neuropsychologia·Marieke van AsselenMiguel Castelo-Branco
Jul 21, 2015·Language Learning and Development : the Official Journal of the Society for Language Development·Joanna C Lee, J Bruce Tomblin
May 17, 2012·Brain Research Bulletin·Simon P Brooks, Stephen B Dunnett
Nov 2, 2013·NeuroImage. Clinical·Eve M DumasUNKNOWN TRACK-HD investigator group
Feb 27, 2007·Neuropsychologia·Nellie Georgiou-KaristianisGary Egan
Mar 20, 2012·Cognition·Brigitte Weiermann, Beat Meier
Jan 28, 2009·Experimental Neurology·Jane S Paulsen
Jul 1, 2014·World Journal of Radiology·Flavia Niccolini, Marios Politis
May 19, 2011·Clinical Neuropharmacology·Mouna EsmaeilzadehJoakim Tedroff
Jan 4, 2008·Human Brain Mapping·Robert C WolfGeorg Bernhard Landwehrmeyer
Jul 9, 2005·Current Opinion in Neurology·Christian Forkstam, Karl Magnus Petersson
Aug 23, 2006·Nature Reviews. Neuroscience·Paul M MatthewsEdward T Bullmore
Apr 9, 2010·Brain : a Journal of Neurology·Doris C V ThuRichard L M Faull
Jun 15, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Susanne A SchneiderMarjan Jahanshahi
Jun 18, 2010·CNS Neuroscience & Therapeutics·Mouna EsmaeilzadehFerdinando Squitieri
Apr 5, 2014·The European Journal of Neuroscience·Robert C WolfMichael Orth
Nov 11, 2019·The European Journal of Neuroscience·Gabriel Ramirez-GarciaAurelio Campos-Romo
Aug 17, 2016·Brain Pathology·Mar PuigdellívolEsther Pérez-Navarro
Jun 27, 2017·Journal of Clinical Movement Disorders·Debra J Ehrlich, Ruth H Walker
May 25, 2018·Behavioural Brain Research·Emma M CoppenRaymund A C Roos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.