PMID: 9180129Jun 1, 1997Paper

Functional myocardial perfusion abnormality induced by left ventricular asynchronous contraction: experimental study using myocardial contrast echocardiography

Journal of the American College of Cardiology
S BeppuK Miyatake

Abstract

The aim of this study was to clarify how myocardial perfusion is impaired by asynchronous contraction. False septal hypoperfusion is noted in some patients with left bundle branch block. Eight dogs were examined with epicardial pacing at the left ventricular posterior wall, the right ventricular anterior wall and, as a control, the right atrial appendage. The pacing rate was 80, 110 and 150 beats/min (bpm). Myocardial perfusion was assessed by contrast echocardiography. Left ventricular pacing at 80 and 110 bpm did not change systolic wall thickening or contrast intensity at the pacing site, although an early excitation notch was noted at the pacing site. However, at 150 bpm, systolic thickening was impaired (23.3 +/- 4.2% vs. 37.0 +/- 2.6% during atrial pacing, p < 0.05), and the peak intensity ratio of the pacing site to the ventricular septum was significantly decreased (24.1 +/- 5.7% vs. 37.0 +/- 2.8% at a pacing rate of 80 bpm, p < 0.01). The peak intensity ratio correlated with systolic wall thickening at the pacing site (y = 0.413 x -0.028, r = 0.81, p < 0.0001). However, right ventricular pacing did not change either systolic thickening or the peak intensity ratio at any pacing rate, although an early excitation notch w...Continue Reading

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Citations

Nov 26, 2010·Heart Failure Reviews·Frits W PrinzenTammo Delhaas
Jan 31, 2004·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Tokuo KasaiArshad Ali Shah
Nov 4, 1998·Seminars in Thoracic and Cardiovascular Surgery·W D Spotnitz, R L Welker
Aug 24, 2006·Journal of Cardiovascular Electrophysiology·Stephane LafittePierre Dos Santos
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·G S NelsonJ V Tyberg

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