Functional network changes and cognitive control in schizophrenia.

NeuroImage. Clinical
Kimberly L RayCameron S Carter

Abstract

Cognitive control is a cognitive and neural mechanism that contributes to managing the complex demands of day-to-day life. Studies have suggested that functional impairments in cognitive control associated brain circuitry contribute to a broad range of higher cognitive deficits in schizophrenia. To examine this issue, we assessed functional connectivity networks in healthy adults and individuals with schizophrenia performing tasks from two distinct cognitive domains that varied in demands for cognitive control, the RiSE episodic memory task and DPX goal maintenance task. We characterized general and cognitive control-specific effects of schizophrenia on functional connectivity within an expanded frontal parietal network (FPN) and quantified network topology properties using graph analysis. Using the network based statistic (NBS), we observed greater network functional connectivity in cognitive control demanding conditions during both tasks in both groups in the FPN, and demonstrated cognitive control FPN specificity against a task independent auditory network. NBS analyses also revealed widespread connectivity deficits in schizophrenia patients across all tasks. Furthermore, quantitative changes in network topology associated w...Continue Reading

Citations

May 7, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Michael F GreenJunghee Lee
Jan 31, 2020·Frontiers in Computational Neuroscience·Dennis Joe HarmahPeng Xu
Sep 5, 2020·Network Neuroscience·Benjamin N ConradGavin R Price
May 28, 2019·Medical & Biological Engineering & Computing·Paula G RodriguesDiogo C Soriano
Dec 8, 2019·Cognitive, Affective & Behavioral Neuroscience·Kimberly L RayCameron S Carter
May 30, 2020·Journal of Psychiatry and Brain Science·Stewart A ShankmanSebastian Walther
Sep 23, 2018·Molecular Psychiatry·J Y GuoC S Carter
Jan 20, 2021·Molecular Psychiatry·Danhong WangDaphne J Holt
Jan 30, 2021·Journal of the International Neuropsychological Society : JINS·Lu-Xia JiaRaymond C K Chan

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Software Mentioned

RiSE
FMRIB Software Library FSL
FSL
FMRI Expert Analysis Tool ( FEAT )
Power atlas
Brain Connectivity Toolbox Statistic
SPM8
CNTRACS

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