Functional Neural Correlates of Slower Gait Among Older Adults With Mild Cognitive Impairment

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Chun Liang HsuTeresa Liu-Ambrose

Abstract

Subtle, but observable, changes in mobility often exist among older adults with mild cognitive impairment (MCI). Notably, these changes are not inconsequential. Therefore, there is a strong interest to better understand the underlying neural correlates of gait slowing among older adults with MCI. In this study, we aimed to characterize patterns of functional connectivity associated with slower gait speed in older adults with MCI. Forty-nine participants aged 60 years and older with MCI were included in the cross-sectional study. All participants underwent assessments of gait speed and resting state functional magnetic resonance imaging. In this sample of older adults with MCI, slower usual gait was characterized by altered connectivity between the sensorimotor network (SMN) and the frontoparietal network (FPN) (p < .05)-specifically, slower usual gait was associated with greater connectivity between the supplementary motor area (SMA) and the bilateral ventral visual cortices (p = .01); lower connectivity between the SMA and the bilateral superior lateral occipital cortex (p < .01); and lower connectivity between the SMA and the bilateral frontal eye field (p < .01). Altered inter-network functional connectivity between the SMN ...Continue Reading

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