Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis

Brain Imaging and Behavior
Michael Matthew FrancisAlan Breier

Abstract

Studies have demonstrated that episodic memory (EM) is often preferentially disrupted in schizophrenia. The neural substrates that mediate EM impairment in this illness are not fully understood. Several functional magnetic resonance imaging (fMRI) studies have employed EM probe tasks to elucidate the neural underpinnings of impairment, though results have been inconsistent. The majority of EM imaging studies have been conducted in chronic forms of schizophrenia with relatively few studies in early phase patients. Early phase schizophrenia studies are important because they may provide information regarding when EM deficits occur and address potential confounds more frequently observed in chronic populations. In this study, we assessed brain activation during the performance of visual scene encoding and recognition fMRI tasks in patients with earlyphase psychosis (n = 35) and age, sex, and race matched healthy control subjects (n = 20). Patients demonstrated significantly lower activation than controls in the right hippocampus and left fusiform gyrus during scene encoding and lower activation in the posterior cingulate, precuneus, and left middle temporal cortex during recognition of target scenes. Symptom levels were not relate...Continue Reading

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Feb 26, 2016·NeuroImage. Clinical·S GuimondM Lepage
Oct 4, 2016·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Damee ChoiShigeki Watanuki
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Apr 22, 2020·Neuropsychobiology·Demet GurlerAdrienne Carol Lahti

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