Functional Neuroanatomical Correlates of The Frontal Assessment Battery Performance in Alzheimer Disease: A FDG-PET Study

Journal of Geriatric Psychiatry and Neurology
Jun Ho LeeDong Young Lee

Abstract

We aimed to elucidate the functional neuroanatomical correlates of Frontal Assessment Battery (FAB) performances by applying [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) to a large population of patients with Alzheimer disease (AD). The FAB was administered to 177 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by FDG-PET scan. Correlations between FAB scores and rCMglc were explored using both region-of-interest-based (ROI-based) and voxel-based approaches. The ROI-based analysis showed that FAB scores correlated with the rCMglc of the dorsolateral prefrontal cortices. Voxel-based approach revealed significant positive correlations between FAB scores and rCMglc which were in various cortical regions including the temporal and parietal cortices as well as frontal regions, independent of age, gender, and education. After controlling the effect of global disease severity with Mini-Mental State Examination score, significant positive correlation was found only in the bilateral prefrontal regions. Although FAB scores are influenced by temporoparietal dysfunction due to the overall progression of AD, it likely reflects prefrontal dysfunction specifically regardless of global cogni...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jun 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·C P HughesR L Martin
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·H Braak, E Braak
Dec 13, 2000·Neurology·B DuboisB Pillon
Mar 4, 2003·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Rebecca E ReadyDeborah A Cahn-Weiner
Aug 27, 2005·The Psychiatric Clinics of North America·Elkhonon Goldberg, Dmitri Bougakov
Nov 30, 2005·Annals of Neurology·Jérémie ParienteRichard S J Frackowiak
Jun 30, 2007·Psychiatry Research·Aki KugoShigetoshi Kuroda
Apr 22, 2008·International Journal of Geriatric Psychiatry·Eun Hyun SeoJong Inn Woo
Feb 3, 2009·Dementia and Geriatric Cognitive Disorders·Hidenori YoshidaShigetoshi Kuroda
Oct 31, 2009·Journal of Psychiatric Research·Stefan FörsterKatharina Bürger
Dec 1, 2009·NeuroImage·J ChumbleyK Friston
Apr 29, 2010·Dementia and Geriatric Cognitive Disorders·Tae Hui KimKi Woong Kim
Sep 3, 2010·Geriatrics & Gerontology International·Kazumasa KumeToshihiko Iwamoto
Jun 17, 2011·Clinical EEG and Neuroscience·Oskar Dieter Peter SchönknechtJohannes Schröder
Jan 6, 2012·International Psychogeriatrics·Etsuko OshimaYosuke Uchitomi

❮ Previous
Next ❯

Citations

Nov 25, 2017·Frontiers in Aging Neuroscience·Helena S MoreiraSelene G Vicente
Mar 12, 2019·Current Alzheimer Research·Kiyotaka NakamagoeAkira Tamaoka
Jun 20, 2017·International Journal of Geriatric Psychiatry·Miriam Hurtado-PomaresEva María Navarrete-Muñoz
Nov 30, 2019·The Journal of Nutrition, Health & Aging·W Y GohW S Lim
Jan 27, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Teruyuki MatsuokaJin Narumoto
Apr 17, 2020·Applied Neuropsychology. Adult·Miroslava AbrahámováMichal Hajdúk
Jul 30, 2020·Annals of Rehabilitation Medicine·Mihyang HanMin-Wook Kim

❮ Previous
Next ❯

Software Mentioned

SB
CDR
Matlab
SPM8
Statistical Parametric Mapping 8 ( SPM8
SPSS

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.