Functional neuroanatomy for pain stimuli. Reception, transmission, and processing

Der Schmerz
S Mense

Abstract

This short overview presents some of the current neuroanatomical knowledge concerning pathways and nuclei mediating pain sensations. The axonal membrane of the nociceptor is equipped with a multitude of receptor molecules that specifically bind pain-producing and sensitizing substances. Recently, adenosine triphosphate and protons have attracted much interest. The different nociceptor types are probably characterized by different sets of receptor molecules in the membrane of the nociceptive ending. Nociceptive cells are present in the superficial laminae and the neck of the dorsal horn. The cells in the former region include nociceptive-specific ones that receive input from nociceptors exclusively, whereas in the neck of the dorsal horn a convergent input from nociceptive and non-nociceptive afferent fibers prevails. At the spinal level, neuroplastic sensitizing processes take place that are assumed to underlie the allodynia and hyperalgesia of pain patients. In addition to the lateral spinothalamic tract, the spinoreticular and spinomesencephalic tracts are involved in pain sensations. The medial and lateral thalamus contains several nociceptive nuclei, the medial ones mediating the affective-emotional component of pain, the l...Continue Reading

Citations

Jul 28, 2005·Der Schmerz·T Weiss, W H R Miltner
Jun 23, 2016·NeuroImage. Clinical·Jürgen HänggiPeter Brugger
Jan 23, 2021·International Journal of Environmental Research and Public Health·Łukasz OleksyArtur Stolarczyk

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