Oct 22, 2003

Functional neuroanatomy of auditory mismatch processing: an event-related fMRI study of duration-deviant oddballs

NeuroImage
U SchallP T Michie

Abstract

This study was designed to identify the neural networks underlying automatic auditory deviance detection in 10 healthy subjects using functional magnetic resonance imaging. We measured blood oxygenation level-dependent contrasts derived from the comparison of blocks of stimuli presented as a series of standard tones (50 ms duration) alone versus blocks that contained rare duration-deviant tones (100 ms) that were interspersed among a series of frequent standard tones while subjects were watching a silent movie. Possible effects of scanner noise were assessed by a "no tone" condition. In line with previous positron emission tomography and EEG source modeling studies, we found temporal lobe and prefrontal cortical activation that was associated with auditory duration mismatch processing. Data were also analyzed employing an event-related hemodynamic response model, which confirmed activation in response to duration-deviant tones bilaterally in the superior temporal gyrus and prefrontally in the right inferior and middle frontal gyri. In line with previous electrophysiological reports, mismatch activation of these brain regions was significantly correlated with age. These findings suggest a close relationship of the event-related ...Continue Reading

  • References33
  • Citations53

References

  • References33
  • Citations53

Citations

Mentioned in this Paper

Alveolar Ventilation Function
Entire Scalp
Cortex Bone Disorders
Adrenal Cortex Diseases
Prefrontal Cortex
Positron-Emission Tomography
Functional Neuroimaging
Malignant Neoplasm of Temporal Lobe
Brain
Neuroanatomy

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