Functional neuroimaging abnormalities in youth with psychosis spectrum symptoms

JAMA Psychiatry
Daniel H WolfRaquel E Gur

Abstract

The continuum view of the psychosis spectrum (PS) implies that, in population-based samples, PS symptoms should be associated with neural abnormalities similar to those found in help-seeking clinical risk individuals and in schizophrenia. To our knowledge, functional neuroimaging has not previously been applied in large population-based PS samples and can help us understand the neural architecture of psychosis more broadly and identify brain phenotypes beyond symptoms that are associated with the extended psychosis phenotype. To examine the categorical and dimensional relationships of PS symptoms to prefrontal hypoactivation during working memory and to amygdala hyperactivation during threat emotion processing. The Philadelphia Neurodevelopmental Cohort is a genotyped, prospectively accrued, population-based sample of almost 10,000 youths who received a structured psychiatric evaluation and a computerized neurocognitive battery. The study was conducted at an academic and children's hospital health care network, between November 1, 2009 to November 30, 2011. A subsample of 1445 youths underwent neuroimaging, including functional magnetic resonance imaging tasks examined herein. Participants were youth aged 11 to 22 years old ide...Continue Reading

Citations

Nov 27, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ruben C Gur, Raquel E Gur
Jun 3, 2015·Molecular Psychiatry·T D SatterthwaiteR E Gur
Oct 30, 2016·International Journal of Methods in Psychiatric Research·Eduardo Fonseca-PedreroJulio Bobes
Jan 12, 2017·Trends in psychiatry and psychotherapy·Ateeq Mubarik, Hassaan Tohid
May 22, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Megan QuarmleyDaniel H Wolf
May 13, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Roman KotovUNKNOWN HiTOP Utility Workgroup
Jul 2, 2020·The American Journal of Psychiatry·Jules R DugréStéphane Potvin
Jul 2, 2020·The American Journal of Psychiatry
Feb 13, 2019·Psychological Medicine·Stephanie N DeCrossDaphne J Holt
Jan 28, 2017·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Monica E CalkinsRaquel E Gur
Dec 20, 2017·Neuropsychobiology·Werner StrikThomas Dierks
Jun 21, 2019·Schizophrenia Bulletin·Eva MennigenCarrie E Bearden
Oct 3, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erica B BallerTheodore D Satterthwaite
Jan 20, 2021·Molecular Psychiatry·Danhong WangDaphne J Holt
Feb 23, 2020·Neuron·Zaixu CuiTheodore D Satterthwaite
May 2, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Kathleen J O'BrienNicole R Karcher
Apr 3, 2021·Clinical Psychology Review·Giorgia MicheliniRoman Kotov
Jun 6, 2021·Translational Psychiatry·Julia M SheffieldNeil D Woodward

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