Functional neuroimaging findings in patients with lateral and mesio-lateral temporal lobe epilepsy; FDG-PET and ictal SPECT studies

Journal of Neurology
Eun Yeon JooSeung Bong Hong

Abstract

The differentiation of combined mesial and lateral temporal onset of seizures (mesio-lateral TLE, MLTLE) from lateral TLE (LTLE) is critical to achieve good surgical outcomes. However, the functional neuroimaging features in LTLE patients based on the ictal onset zone utilizing intracranial EEG (iEEG) in a large series have not been investigated. We enrolled patients diagnosed with MLTLE (n = 35) and LTLE (n = 53) based on the site of ictal onset zone from iEEG monitoring. MLTLE is defined when ictal discharges originate from the mesial and lateral temporal cortices independently, whereas seizures of LTLE arise exclusively from the lateral temporal cortex. Compared to patients with LTLE, patients with MLTLE were more likely to have 18F- fluorodeoxyglucose positron emission tomography (FDG-PET) hypometabolism and hyperperfusion on ictal single-photon emission computed tomography (SPECT) restricted to the temporal areas. MLTLE patients had more frequent aura or secondarily generalized seizures than LTLE patients. No significant differences were found in scalp EEG, MRI, and Wada asymmetry between groups. The overall seizure-free rate was good (73.8%, mean follow-up = 9.7 years), which was not different (Engel class I, 74.3% in MLT...Continue Reading

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Aug 21, 2007·Epilepsy & Behavior : E&B·Jee Hyun KimSeung Bong Hong

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Citations

Aug 23, 2019·Brain : a Journal of Neurology·Jyun-You LiouTheodore H Schwartz
Sep 25, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Trina MitchellCaroline Paquette
Apr 23, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Cristina Elena PopescuFederico Caobelli
Jan 10, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Qinming ZhangMei Tian

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