Functional neuroimaging in subjective cognitive decline: current status and a research path forward

Alzheimer's Research & Therapy
Raymond P Viviano, Jessica S Damoiseaux

Abstract

Subjective cognitive decline is a putative precursor to dementia marked by perceived worsening of cognitive function without overt performance issues on neuropsychological assessment. Although healthy older adults with subjective cognitive decline may function normally, perceived worsening may indicate incipient dementia and predict future deterioration. Therefore, the experience of decline represents a possible entry point for clinical intervention. However, intervention requires a physical manifestation of neuroabnormality to both corroborate incipient dementia and to target clinically. While some individuals with subjective cognitive decline may harbor pathophysiology for specific neurodegenerative disorders, many do not display clear indicators. Thus, disorder-agnostic brain measures could be useful to track the trajectory of decline, and functional neuroimaging in particular may be sensitive to detect incipient dementia and have the ability to track disease-related change when the underlying disease etiology remains unclear. Therefore, in this review, we discuss functional neuroimaging studies of subjective cognitive decline and possible reconciliations to inconsistent findings. We conclude by proposing a functional model ...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Sep 1, 1985·The American Journal of Psychiatry·D A PlotkinL F Jarvik
Jul 13, 2001·Nature·N K LogothetisA Oeltermann
Aug 18, 2004·Journal of Neurology·Wiesje M van der FlierHuub A M Middelkoop
Nov 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·W M van der Flier, P Scheltens
Nov 29, 2005·Neurobiology of Aging·Frank JessenLukas Scheef
Mar 18, 2006·Journal of Integrative Neuroscience·David M AlexanderEvian Gordon
Oct 19, 2006·Dementia and Geriatric Cognitive Disorders·Louise M Reid, Alasdair M J Maclullich
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Jun 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Nico U F DosenbachSteven E Petersen
Apr 25, 2008·European Psychiatry : the Journal of the Association of European Psychiatrists·Khaled Abdulrab, Reinhard Heun
Jul 22, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Barry ReisbergMony J de Leon
Oct 9, 2008·Dementia and Geriatric Cognitive Disorders·Ralf TepestFrank Jessen
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
Mar 5, 2009·International Journal of Geriatric Psychiatry·Joanne E RoddaZuzana Walker
Jan 14, 2010·Neuromolecular Medicine·Reisa A SperlingKeith A Johnson
Jan 30, 2010·Dementia and Geriatric Cognitive Disorders·Nadine StriepensFrank Jessen
Feb 5, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Barry ReisbergWei Zhu
Apr 7, 2010·Archives of General Psychiatry·Frank JessenUNKNOWN German Study on Aging, Cognition and Dementia in Primary Care Patients Study Group
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Sep 10, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fernando MaestuAngel Nevado
Oct 12, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·J RoddaZ Walker
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yvette I ShelineMark A Mintun
Apr 16, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Melissa J SlavinPerminder S Sachdev
May 3, 2011·Neuropsychologia·Kerryn E PikeChristopher C Rowe
Jun 28, 2011·Nature Methods·Tal YarkoniTor D Wager
Aug 4, 2011·Archives of General Psychiatry·Susanne ErkFrank Jessen
Sep 4, 2012·Neuropsychologia·Rebecca E AmariglioDorene M Rentz
Sep 21, 2012·Nature Reviews. Neuroscience·Charan Ranganath, Maureen Ritchey
Oct 6, 2012·Neurobiology of Aging·Julie A DumasPaul A Newhouse
Dec 12, 2012·Acta Neurologica Scandinavica·Y BalashA D Korczyn
Feb 5, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN German Study on Aging, Cognition and Dementia in Primary Care Patients
Mar 7, 2013·Archives of Gerontology and Geriatrics·Min-Jeong KimDuk L Na
May 1, 2013·Brain Connectivity·Anne HafkemeijerSerge A R B Rombouts

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Citations

Dec 20, 2020·Experimental Gerontology·Lorenzo Pini, Alexandra M Wennberg
May 7, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yaoyu ZhangJia-Hong Gao
Jun 2, 2021·Alzheimer's Research & Therapy·Raymond P Viviano, Jessica S Damoiseaux
Jun 11, 2021·European Radiology·Haifeng ChenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 4, 2021·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Adriana L Ruiz-RizzoJessica S Damoiseaux

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Software Mentioned

Local Analysis of Mixed
FMRIB
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