Functional Neuroimaging of Nociceptive and Pain-Related Activity in the Spinal Cord and Brain: Insights From Neurovascular Coupling Studies

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Thierry PaquetteMathieu Piché

Abstract

Spinal cord and brain processes underlie pain perception, which produces systemic cardiovascular changes. In turn, the autonomic nervous system regulates vascular function in the spinal cord and brain in order to adapt to these systemic changes, while neuronal activity induces local vascular changes. Thus, autonomic regulation and pain processes in the brain and spinal cord are tightly linked and interrelated. The objective of this topical review is to discuss work on neurovascular coupling during nociceptive processing in order to highlight supporting evidence and limitations for the use of cerebral and spinal fMRI to investigate pain mechanisms and spinal nociceptive processes. Work on functional neuroimaging of pain is presented and discussed in relation to available neurovascular coupling studies and related issues. Perspectives on future work are also discussed with an emphasis on differences between the brain and the spinal cord and on different approaches that may be useful to improve current methods, data analyses and interpretation. In summary, this review highlights the lack of data on neurovascular coupling during nociceptive stimulation and indicates that hemodynamic and BOLD responses measured with fMRI may be bias...Continue Reading

References

Jan 1, 1976·Journal of Neurosurgery·A I KobrineH V Rizzoli
Apr 1, 1976·Journal of Neurosurgery·A I KobrineH V Rizzoli
Jul 1, 1977·Circulation Research·M L MarcusF M Abboud
Dec 1, 1991·Anesthesia and Analgesia·W E HoffmanR F Albrecht
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S OgawaD W Tank
Nov 1, 1986·Stroke; a Journal of Cerebral Circulation·R HickeyJ Gelineau
Dec 15, 1995·The Journal of Physiology·M Nordin, J Fagius
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·R PórszászM Rudin
Apr 16, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G BrinkerM Hoehn-Berlage
Jul 14, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B M AncesJ A Detre
Dec 29, 2000·Neurophysiologie clinique = Clinical neurophysiology·R PeyronL García-Larrea
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·A DarquiéD Le Bihan
Nov 2, 2002·Journal of Magnetic Resonance Imaging : JMRI·Krisztina L Malisza, Patrick W Stroman
May 29, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·John MartindaleYing Zheng
Jun 5, 2003·Nature Reviews. Neuroscience·Denis Le Bihan
Jul 29, 2003·Journal of Magnetic Resonance Imaging : JMRI·Krisztina L MaliszaAnthony Wright
Sep 16, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kazuto MasamotoKazuo Tanishita
Feb 24, 2004·Annual Review of Physiology·Nikos K Logothetis, Brian A Wandell
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masahito NemotoArthur W Toga
Jun 15, 2004·NeuroImage·Myles JonesJohn Mayhew
Jan 4, 2005·NeuroImage·Nicola Hewson-StoateJohn Mayhew
Feb 11, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·John MartindaleJohn Mayhew
Mar 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anna DevorAnders M Dale
Jun 28, 2005·European Journal of Pain : EJP·A Vania ApkarianJon-Kar Zubieta
May 9, 2006·Autonomic Neuroscience : Basic & Clinical·Mieko KurosawaBrian Budgell
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Denis Le BihanHidenao Fukuyama
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Johan LiljaChristian Spenger
Feb 16, 2007·NeuroImage·Andrew S LoweSteve C R Williams

❮ Previous
Next ❯

Citations

Aug 28, 2019·Scientific Reports·Chiao-Chi ChenGuo-Shu Huang
May 30, 2021·The Journal of Physiological Sciences : JPS·Thierry PaquetteHugues Leblond

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.