Sep 30, 2000

Functional neuroimaging of normal human sleep by positron emission tomography

Journal of Sleep Research
Pierre Maquet

Abstract

Functional neuroimaging using positron emission tomography has recently yielded original data on the functional neuroanatomy of human sleep. This paper attempts to describe the possibilities and limitations of the technique and clarify its usefulness in sleep research. A short overview of the methods of acquisition and statistical analysis (statistical parametric mapping, SPM) is presented before the results of PET sleep studies are reviewed. The discussion attempts to integrate the functional neuroimaging data into the body of knowledge already acquired on sleep in animals and humans using various other techniques (intracellular recordings, in situ neurophysiology, lesional and pharmacological trials, scalp EEG recordings, behavioural or psychological description). The published PET data describe a very reproducible functional neuroanatomy in sleep. The core characteristics of this 'canonical' sleep may be summarized as follows. In slow-wave sleep, most deactivated areas are located in the dorsal pons and mesencephalon, cerebellum, thalami, basal ganglia, basal forebrain/hypothalamus, prefrontal cortex, anterior cingulate cortex, precuneus and in the mesial aspect of the temporal lobe. During rapid-eye movement sleep, signific...Continue Reading

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Mentioned in this Paper

Cortex Bone Disorders
Adrenal Cortex Diseases
Prefrontal Cortex
Thalamic Nuclei
Structure of Tegmental Portion of Pons
Positron-Emission Tomography
Functional Neuroimaging
Neurophysiology - Biologic Function
Dreams
Sleep, Slow-Wave

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