Functional neuroimaging study in identical twin pairs discordant for regular cigarette smoking.

Addiction Biology
Christina N Lessov-SchlaggarDeanna M Barch

Abstract

Despite the tremendous public health and financial burden of cigarette smoking, relatively little is understood about brain mechanisms that subserve smoking behavior. This study investigated the effect of lifetime regular smoking on brain processing in a reward guessing task using functional magnetic resonance imaging and a co-twin control study design in monozygotic (MZ) twin pairs that maximally controls for genetic and family background factors. Young adult (24-34 years) MZ female twin pairs (n = 15 pairs), discordant for regular smoking defined using Centers for Disease Control criteria as having smoked ≥100 cigarettes in their lifetime, were recruited from an ongoing genetic epidemiological longitudinal study of substance use and psychopathology. We applied hypothesis-driven region of interest (ROI) and whole-brain analyses to investigate the effect of regular smoking on reward processing. Reduced response to reward and punishment in regular compared with never-regular smokers was seen in hypothesis-driven ROI analysis of bilateral ventral striatum. Whole-brain analysis identified bilateral reward-processing regions that showed activation differences in response to winning or losing money but no effect of regular smoking; ...Continue Reading

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Citations

Jul 22, 2014·Current Behavioral Neuroscience Reports·Catherine H DemersArpana Agrawal
May 23, 2015·Addiction Biology·Rick E Bernardi
Jul 5, 2016·Frontiers in Neuroscience·Christina N Lessov-SchlaggarBradley L Schlaggar
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May 17, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Rebecca J BrookerH Hill Goldsmith

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