Functional neuroimaging with positron emission tomography

Epilepsia
T R Henry

Abstract

Epilepsy research using positron emission tomography (PET) has provided considerable new information about ictal and interictal dysfunctions in human epilepsy. Neuroreceptor mapping with PET ligands has revealed altered central benzodiazepine receptor and opiate receptor densities in partial epilepsies interictally, and regional increases in endogenous opioid peptide concentrations during absence seizures. Imaging of perfusion and glucose metabolism during cognitive processing has shown interictal abnormalities of regional activation in partial and generalized epilepsies. The diagnostically robust patterns of interictal glucose hypometabolism are not adequately explained by macrostructural and microstructural alterations in temporal lobe epilepsy. Current investigations of the pathophysiology of interictal hypometabolism must address ultrastructural and neurochemical factors. Clinical PET in presurgical evaluation of medically refractory epilepsies remains an active area of research, but remarkably little antiepileptic drug research has exploited PET techniques.

References

Dec 1, 1992·Annals of Neurology·W H TheodoreD B Leiderman
Jun 1, 1992·Archives of Neurology·E B BromfieldW H Theodore
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeD E Kuhl
Nov 11, 1991·Epilepsy Research·T R HenryM E Phelps
Jan 1, 1991·Progress in Neurobiology·L Sivilotti, A Nistri
Aug 1, 1991·Brain : a Journal of Neurology·R WiseR Frackowiak
May 1, 1991·Epilepsy Research·M HajekH G Wieser
May 1, 1991·Epilepsia·D B LeidermanW H Theodore
Jun 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J J FrostH N Wagner
Dec 1, 1989·Annals of Neurology·L JunckS Starosta-Rubinstein
Jan 1, 1988·Epilepsia·W H Theodore
Jan 1, 1987·Annals of Neurology·W H TheodoreD Fishbein
Jan 1, 1986·Progress in Neurobiology·P Kása
Mar 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J C MazziottaK Mahoney
Feb 1, 1985·Annals of Neurology·J EngelM E Phelps
Sep 23, 1982·Brain Research·A PfeifferA Herz
Jan 1, 1984·Annals of Neurology·R A NovellyS S Spencer
Dec 1, 1982·Annals of Neurology·J EngelP H Crandall

❮ Previous
Next ❯

Citations

Mar 20, 2002·Current Neurology and Neuroscience Reports·S TigaranG D Cascino
May 21, 2003·Seminars in Nuclear Medicine·Thomas R Henry, Ronald L Van Heertum
May 24, 2000·Nuclear Medicine Communications·S F Barrington
Dec 22, 1998·Epilepsia·B DiehlS R Stodieck
Mar 28, 2009·Epilepsia·Clementina Van Rijn, Harry Meinardi
Apr 29, 1998·Current Opinion in Neurology·W Boling, A Olivier
Sep 24, 2004·Epilepsy Research·Gregory D Cascino
Aug 25, 2004·Neuroimaging Clinics of North America·Thomas R Henry, John R Votaw
Aug 25, 2004·Neuroimaging Clinics of North America·Gregory D CascinoBrian P Mullan
Apr 12, 2005·Epilepsy & Behavior : E&B·M Lopez-GomezI Ruiz
Aug 21, 2007·Seminars in Nuclear Medicine·Shekhar PatilLise Borgwardt
Jun 26, 2001·Acta Neurologica Scandinavica·E KumlienM Bergström

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.