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Functional normalization of 450k methylation array data improves replication in large cancer studies

bioRxiv

Feb 23, 2014

Jean-Philippe FortinKasper Daniel Hansen

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Abstract

We propose an extension to quantile normalization which removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic...read more

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Probes
Study of Epigenetics
Study
Array
Genome
Virus Replication
Research Study
Human Activity Profile Test
Methylation
Case-Control Studies
10
109
Paper Details
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  • Functional normalization of 450k methylation array data improves replication in large cancer studies

    bioRxiv

    Feb 23, 2014

    Jean-Philippe FortinKasper Daniel Hansen

    PMID: 990002956

    DOI: 10.1101/002956

    Abstract

    We propose an extension to quantile normalization which removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic...read more

    Mentioned in this Paper

    Probes
    Study of Epigenetics
    Study
    Array
    Genome
    10
    109
    Paper Details
    References
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