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Functional normalization of 450k methylation array data improves replication in large cancer studies

bioRxiv

Feb 23, 2014

Jean-Philippe FortinKasper D Hansen

Abstract

We propose an extension to quantile normalization which removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic...read more

Mentioned in this Paper

Array
Study of Epigenetics
Human Activity Profile Test
Methylation
Normalize
Study
Virus Replication
Adapt (substance)
Microarray Platform
Malignant Neoplasms
12
109
Paper Details
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Functional normalization of 450k methylation array data improves replication in large cancer studies

bioRxiv

Feb 23, 2014

Jean-Philippe FortinKasper D Hansen

PMID: 990002956

DOI: 10.1101/002956

Abstract

We propose an extension to quantile normalization which removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic...read more

Mentioned in this Paper

Array
Study of Epigenetics
Human Activity Profile Test
Methylation
Normalize
Study
Virus Replication
Adapt (substance)
Microarray Platform
Malignant Neoplasms
12
109

Similar Papers Found In These Feeds

Paper Details
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