Functional optical coherence tomography of neurovascular coupling interactions in the retina

Journal of Biophotonics
Taeyoon SonXin-Cheng Yao

Abstract

Quantitative evaluation of retinal neurovascular coupling is essential for a better understanding of visual function and early detection of eye diseases. However, there is no established method to monitor coherent interactions between stimulus-evoked neural activity and hemodynamic responses at high resolution. Here, we report a multimodal functional optical coherence tomography (OCT) imaging methodology to enable concurrent intrinsic optical signal (IOS) imaging of stimulus-evoked neural activity and hemodynamic responses at capillary resolution. OCT angiography guided IOS analysis was used to separate neural-IOS and hemodynamic-IOS changes in the same retinal image sequence. Frequency flicker stimuli evoked neural-IOS changes in the outer retina; that is, photoreceptor layer, first and then in the inner retina, including outer plexus layer (OPL), inner plexiform layer (IPL), and ganglion cell layer (GCL), which were followed by hemodynamic-IOS changes primarily in the inner retina; that is, OPL, IPL, and GCL. Different time courses and signal magnitudes of hemodynamic-IOS responses were observed in blood vessels with various diameters.

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Citations

Jun 20, 2020·Experimental Biology and Medicine·Xincheng Yao, Tae-Hoon Kim
Oct 1, 2020·Scientific Reports·Raymond L WarnerStephen A Burns
Jan 9, 2019·Translational Vision Science & Technology·Tae-Hoon KimXincheng Yao
Nov 30, 2018·Experimental Biology and Medicine·Xincheng YaoYiming Lu
Dec 15, 2020·Experimental Biology and Medicine·Taeyoon SonXincheng Yao

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