Functional organization of postsynaptic glutamate receptors

Molecular and Cellular Neurosciences
Nicky Scheefhals, Harold D MacGillavry

Abstract

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the brain, responsible for mediating the vast majority of excitatory transmission in neuronal networks. The AMPA- and NMDA-type ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the fast synaptic responses, while metabotropic glutamate receptors (mGluRs) are coupled to downstream signaling cascades that act on much slower timescales. These functionally distinct receptor sub-types are co-expressed at individual synapses, allowing for the precise temporal modulation of postsynaptic excitability and plasticity. Intriguingly, these receptors are differentially distributed with respect to the presynaptic release site. While iGluRs are enriched in the core of the synapse directly opposing the release site, mGluRs reside preferentially at the border of the synapse. As such, to understand the differential contribution of these receptors to synaptic transmission, it is important to not only consider their signaling properties, but also the mechanisms that control the spatial segregation of these receptor types within synapses. In this review, we will focus on the mechanisms that control the organization of glutamate recept...Continue Reading

Citations

Nov 1, 2018·Current Medicinal Chemistry·Xinwang YangEng-Ang Ling
Feb 20, 2020·Critical Reviews in Toxicology·N I Agalakova, O V Nadei
Apr 8, 2020·Nanoscale·Shekhar KediaDeepak Nair
Mar 2, 2019·International Journal of Molecular Sciences·András Mihály
Feb 23, 2020·Frontiers in Pharmacology·Valerie Abigail Nirenberg, Ofer Yifrach
Apr 8, 2020·Frontiers in Cellular Neuroscience·Christos Galanis, Andreas Vlachos
Jul 24, 2020·Cellular and Molecular Neurobiology·Rodrigo G Mira, Waldo Cerpa
Sep 12, 2019·Physiological Reviews·Nora D VolkowRuben Baler
Jul 18, 2019·Frontiers in Molecular Neuroscience·Xiaojuan Yang, Christian G Specht
Aug 4, 2020·Neural Development·Vivian T ChouDavid Van Vactor
Nov 30, 2019·Frontiers in Cellular Neuroscience·Dennis L H Kruijssen, Corette J Wierenga
Dec 6, 2020·Protein & Cell·Jinyi ZhangTian Hua
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Daymara Mercerón-MartínezAdrian G Palacios
Mar 7, 2021·Pharmacological Reviews·Jaclyn N HighlandTodd D Gould
May 1, 2021·Nature Neuroscience·Tomohisa HosokawaYasunori Hayashi
May 18, 2021·Frontiers in Neuroscience·Ezio CarboniAntonello Novelli
Aug 4, 2021·Advanced Healthcare Materials·Cara T MotzCheng Zhu
May 22, 2020·ACS Chemical Neuroscience·Alejandro Sánchez-MelgarMairena Martín
Oct 14, 2021·Cell Death & Disease·You WangTao Xu
Nov 3, 2021·Physiological Reviews·Carolin Wichmann, Thomas Kuner

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy
super-resolution microscopy
fluorescence recovery after photobleaching

Software Mentioned

dSTORM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Victoria Coutinho, Thomas Knöpfel
Frontiers in Cellular Neuroscience
Sriharsha Kantamneni
© 2022 Meta ULC. All rights reserved