Functional outcome after intracerebral haemorrhage - a review of the potential role of antiapoptotic agents

Reviews in the Neurosciences
Abubakar Tijjani SalihuJafri Malin Abdullah

Abstract

Intracerebral haemorrhage (ICH) is the second most common form of stroke and is associated with greater mortality and morbidity compared with ischaemic stroke. The current ICH management strategies, which mainly target primary injury mechanisms, have not been shown to improve patient's functional outcome. Consequently, multimodality treatment approaches that will focus on both primary and secondary pathophysiology have been suggested. During the last decade, a proliferation of experimental studies has demonstrated the role of apoptosis in secondary neuronal loss at the periphery of the clot after ICH. Subsequently, the value of certain antiapoptotic agents in reducing neuronal death and improving functional outcome following ICH was evaluated in animal models. Preliminary evidence from those studies strongly supports the potential role of antiapoptotic agents in reducing neuronal death and improving functional outcome after intracerebral haemorrhage. Expectedly, the ongoing and subsequent clinical trials will substantiate these findings and provide clear information on the most potent and safe antiapoptotic agents, their appropriate dosage, and temporal window of action, thereby making them suitable for the multimodality treatm...Continue Reading

References

Jun 1, 1993·Free Radical Biology & Medicine·S C Bondy, C P LeBel
Jun 1, 1996·Stroke; a Journal of Cerebral Circulation·P H Chan
Aug 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P MacManus, M D Linnik
Sep 10, 1998·Stroke; a Journal of Cerebral Circulation·M AltumbabicM R Del Bigio
Feb 5, 1999·Stroke; a Journal of Cerebral Circulation·E TarkowskiA Tarkowski
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A N MurphyM F Beal
Nov 5, 1999·Stroke; a Journal of Cerebral Circulation·S L HickenbottomJ Aronowski
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K MatsushitaE H Lo
Oct 3, 2000·The American Journal of Medicine·L S Honig, R N Rosenberg
Nov 9, 2000·Anaesthesia·P C Kam, N I Ferch
Nov 25, 2000·British Medical Bulletin·M S Siddique, A D Mendelow
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
May 23, 2001·Leukemia·P P RuvoloW S May
Sep 8, 2001·The New England Journal of Medicine·M O McCarron, J A Nicoll
Aug 31, 2002·Glia·Gary A Rosenberg
Mar 22, 2003·Stroke; a Journal of Cerebral Circulation·O P M TeernstraUNKNOWN Multicenter randomized controlled trial (SICHPA)
Apr 17, 2003·Cerebrovascular Diseases·Martin S Dennis
Apr 18, 2003·Neurosurgery·Adnan I QureshiL Nelson Hopkins
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Cecilia M P RodriguesClifford J Steer
Nov 5, 2003·Annals of Neurology·Jian WangStella E Tsirka
Feb 6, 2004·Stroke; a Journal of Cerebral Circulation·Costantino Iadecola, Philip B Gorelick
Nov 6, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jiping TangJohn H Zhang
Jun 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Karel Chalupsky, Hua Cai
May 5, 2006·Acta Neurochirurgica. Supplement·P S BhattathiriUNKNOWN STICH Investigators
Aug 5, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Norihiro NagaiSusumu Ishida
Nov 23, 2006·Neurology India·Xiangjian ZhangChunyan Li
May 26, 2007·Brain : a Journal of Neurology·Jian Wang, Sylvain Doré
May 26, 2007·Stroke; a Journal of Cerebral Circulation·Adnan I QureshiWayne H Giles
Jun 1, 2007·The Journal of Pharmacology and Experimental Therapeutics·Keun-Hwa JungJae-Kyu Roh
Apr 12, 2008·Stroke; a Journal of Cerebral Circulation·Pilar DelgadoJoan Montaner
May 16, 2008·The New England Journal of Medicine·Stephan A MayerUNKNOWN FAST Trial Investigators
Dec 11, 2008·Acta Neurochirurgica. Supplement·J F ClarkG J Pyne-Geithman
Dec 11, 2008·Acta Neurochirurgica. Supplement·Y HeG Xi
Dec 11, 2008·Acta Neurochirurgica. Supplement·F SharpB P Ander
Dec 11, 2008·Acta Neurochirurgica. Supplement·Y GongY Hua

❮ Previous
Next ❯

Citations

Aug 21, 2018·Journal of Cellular Biochemistry·AmirReza HesariAmirhossein Sahebkar
Jan 13, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Leonardo LorenteAlejandro Jiménez
Nov 16, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Xi-Chang LiuGang Wu
Nov 1, 2021·Anaesthesia Critical Care & Pain Medicine·Leonardo LorenteAntonia Pérez-Cejas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The Cochrane Database of Systematic Reviews
Jie YangHongdong Zhao
Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Navdeep Sangha, Nicole R Gonzales
© 2022 Meta ULC. All rights reserved