Functional outcome in patients with osteosarcoma around the knee joint treated by minimised surgery.

International Orthopaedics
K HayashiKatsuro Tomita

Abstract

The functional results of prostheses and osteoarticular grafts for osteosarcoma around the knee joint are not satisfactory because of poor durability and gross distortion of the normal anatomy. We have investigated the functional outcome of intentional marginal excision for osteosarcoma around the knee joint in conjunction with caffeine-potentiated chemotherapy. Twenty-one patients with AJCC stage IIB high-grade osteosarcoma around the knee joint were given three to five preoperative courses of intra-arterial cisplatin and caffeine with or without doxorubicin. The histological response in these 21 patients to preoperative chemotherapy was grade IV (no viable cells) in 19 patients and grade III (only scattered foci of viable cells) in 2. The patients were separated into three groups on the basis of patterns of tumour excision. The first group underwent marginal excision of the proximal fibula, the second underwent epiphysis preservation followed by distraction osteogenesis, and the third underwent joint resection and reconstruction. The mean functional evaluations were 100, 95, and 88%, respectively. No local tumour recurrence was seen at mean follow-up of 97 months. Marginal excision of the proximal fibula resulted in excellent...Continue Reading

References

Jun 3, 2000·Pediatric Radiology·F A HofferT Laor
Feb 12, 2002·The Journal of Bone and Joint Surgery. British Volume·G BacciE Pignotti
Dec 5, 2002·The Journal of Bone and Joint Surgery. British Volume·H TsuchiyaK Tomita
May 28, 2003·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Norio YamamotoKatsuro Tomita
Dec 14, 2004·The Journal of Bone and Joint Surgery. American Volume·D Luis MuscoloMaximiliano Ranalletta
Sep 6, 2005·The Journal of Bone and Joint Surgery. American Volume·D Luis MuscoloMaximiliano Ranalletta

❮ Previous
Next ❯

Citations

Mar 16, 2011·International Orthopaedics·Xin LiRichard D Lackman
Jul 25, 2013·International Journal of Clinical Oncology·Katsuhiro HayashiTakanobu Otsuka
Nov 14, 2014·World Journal of Surgical Oncology·Ming XuXiuChun Yu
Oct 26, 2012·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Koji WatanabeIssei Nomura
Jun 6, 2009·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Katsuhiro HayashiKatsuro Tomita
Aug 1, 2009·Orthopaedic Surgery·Xiu-chun YuSong-feng Xu
Jan 4, 2012·Journal of Surgical Oncology·Wei-Ming ChenTain-Hsiung Chen
Nov 22, 2013·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kimo C StineCharles K Lumpkin
Feb 13, 2013·Plastic Surgery International·Kashif AbbasHaroon Ur Rashid
May 23, 2015·World Journal of Surgical Oncology·Zhengxiao OuyangXianan Li
Oct 21, 2014·Acta ortopedica brasileira·Luciana NakayaAntonio Sérgio Petrilli
Sep 5, 2014·The Cochrane Database of Systematic Reviews·Elvira C van DalenLeontien C M Kremer
Feb 16, 2021·World Journal of Clinical Cases·Katsuhiro HayashiHiroyuki Tsuchiya
Jun 19, 2021·International Journal of Surgery Case Reports·Ahmed A EldesouqiYing-Lee Lam
Jul 24, 2021·Indian Journal of Surgical Oncology·Manish PruthiSunil Pasricha

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.