Functional Outcomes of Intravenous Thrombolysis in Octogenarians and Nonagenarians Through Telestroke: Single-Center Experience.

Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association
Tarun GirotraChristine A Holmstedt

Abstract

Background: Patients aged ≥80 years are often underrepresented in stroke trials. Observational studies have shown that older patients have worse outcomes compared with younger patients, but outcomes in patients aged ≥80 years treated with intravenous (IV)-alteplase specifically through telestroke (TS) have not been studied. Aim: To compare clinical and safety outcomes in stroke patients aged ≥80 and 60-79 years treated with IV-alteplase via TS. Methods: The Medical University of South Carolina TS database was analyzed to identify IV-alteplase-treated patients aged 60-79 and ≥80 years between January 2015 and March 2018. Baseline demographics and TS-specific variables were compared. Clinical outcomes were assessed using the 90-day modified Rankin Scale (mRS). Safety outcomes were evaluated by comparing symptomatic intracranial hemorrhage (sICH). Multivariate logistic regression analysis was performed to determine odds ratio (OR) for good outcome (mRS 0-2) in the older age group at 90 days. Results: IV-alteplase was used in 151 patients in ≥80 years age group and 273 patients in 60-79 years age group. The older age group had more women and a higher National Institutes of Health Stroke Scale. The mean "ED-door-to-TS-consultant-log...Continue Reading

References

Feb 13, 2004·Age and Ageing·Lars Peter KammersgaardUNKNOWN Copenhagen Stroke Study
Oct 26, 2005·European Neurology·Chin-I ChenAndrei V Alexandrov
Nov 23, 2005·Clinical Neurology and Neurosurgery·Adrià ArboixMiquel Balcells
Feb 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·R J van OostenbruggeJ Lodder
Mar 1, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·P N SylajaUNKNOWN Canadian Alteplase for Stroke Effectiveness Study (CASES) Investigators
Dec 13, 2007·Cerebrovascular Diseases·Danilo ToniMassimiliano Prencipe
Jun 17, 2008·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikUNKNOWN Stroke Outcome Research Canada (SORCan) Working Group
Jul 1, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·Y BejotM Giroud
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Gary A FordNils Wahlgren
Mar 10, 2012·Neurology·D ToniUNKNOWN SITS investigators
Mar 22, 2012·Frontiers in Neurology·Robert J AdamsTanya N Turan
Oct 12, 2012·Neurology·Brett M KisselaDawn O Kleindorfer
Nov 22, 2013·Acta Neurologica Scandinavica·H NaessU Waje-Andreassen
Nov 30, 2013·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Michael KulcsarMary G George
Jun 21, 2014·Stroke; a Journal of Cerebral Circulation·Andrea D BoanDaniel T Lackland
Aug 26, 2014·Stroke; a Journal of Cerebral Circulation·Peter Müller-BarnaHeinrich J Audebert
Feb 9, 2017·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Sami Al KasabChristine Ann Holmstedt
Jun 3, 2017·Journal of the American Geriatrics Society·Francisco PurroyUNKNOWN Catalan Stroke Code and Reperfusion Consortium
Aug 19, 2017·Stroke; a Journal of Cerebral Circulation·Tarvinder SinghClaire J Creutzfeldt
Jan 26, 2018·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Sami Al KasabChristine A Holmstedt
Sep 27, 2018·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Eyad AlmallouhiSami Al Kasab
Feb 14, 2019·Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association·Mohammad AnadaniChristine A Holmstedt

❮ Previous
Next ❯

Citations

May 9, 2019·Current Treatment Options in Neurology·Tiberiu A PanaPhyo K Myint

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Telemedicine Journal and E-health : the Official Journal of the American Telemedicine Association
Sami Al KasabChristine A Holmstedt
Journal of the American Geriatrics Society
Francisco PurroyCatalan Stroke Code and Reperfusion Consortium
© 2022 Meta ULC. All rights reserved