Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis

The Journal of Investigative Dermatology
Carole A PerruzziD R Senger

Abstract

Angiogenesis requires endothelial cell survival and proliferation, which depend upon cytokine stimulation together with integrin-mediated cell adhesion to extracellular matrix; however, the question of which specific integrins are the best targets for suppressing neovascularization is controversial and unresolved. Therefore, we designed experiments to compare contributions of individual integrins from both the alphav and beta1 integrin subfamilies. With immobilized antibodies, we determined that adhesion through integrins alpha1beta1, alpha2beta1, alphavbeta3, and alphavbeta5 each individually supported dermal microvascular endothelial cell survival. Also, substratum coated with collagen I (which binds alpha1beta1 and alpha2beta1) and vitronectin (which binds alphavbeta3 and alphavbeta5) each supported survival. Importantly, substratum coated with combinations of collagen I and vitronectin were most effective at promoting survival, and survival on three-dimensional collagen I gels was strongly enhanced by vitronectin. Vascular endothelial growth factor activation of the p44/p42 mitogen-activated protein kinase pathway, which is required for angiogenesis, was supported by adhesion through either alpha1beta1, alpha2beta1, alphavb...Continue Reading

References

Dec 1, 1992·The Journal of Investigative Dermatology·R A SwerlickT J Lawley
Jan 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C J DrakeC D Little
Aug 1, 1990·The Journal of Cell Biology·M J IgnatiusL F Reichardt
Nov 1, 1989·The Journal of Cell Biology·L R LanguinoE Ruoslahti
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M J Elices, M E Hemler
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Dec 1, 1995·Science·M FriedlanderD A Cheresh
Apr 22, 1994·Science·P C BrooksD A Cheresh
Oct 1, 1995·The Journal of Clinical Investigation·P C BrooksD A Cheresh
Feb 1, 1994·The Journal of Cell Biology·S M Frisch, H Francis
Oct 1, 1993·Analytical Biochemistry·E Holmes, E Engvall
Sep 1, 1993·Molecular Biology of the Cell·J E MeredithM A Schwartz
Jan 1, 1995·Breast Cancer Research and Treatment·N Ferrara
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·M FriedlanderD A Cheresh
Oct 6, 1997·The Journal of Cell Biology·W BlochR Fässler
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·D R SengerM Detmar
Jul 22, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R GattiG C Gazzola
Aug 7, 1998·Molecular Biology of the Cell·S M ShortR L Juliano
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R O HynesK Hodivala-Dilke
Aug 14, 1999·Science·F G Giancotti, E Ruoslahti
Mar 11, 2000·Molecular Biology of the Cell·M Le GallE Van Obberghen-Schilling
Aug 17, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·K Roovers, R K Assoian

❮ Previous
Next ❯

Citations

Jun 15, 2007·Archives of Ophthalmology·Lu ChenM Reza Dana
Jan 15, 2010·Journal of Ocular Biology, Diseases, and Informatics·Jing CuiPeter Baciu
Feb 8, 2011·Integrative Biology : Quantitative Biosciences From Nano to Macro·Ravi A DesaiChristopher S Chen
Jan 12, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Areck A UcuzianHoward P Greisler
Aug 3, 2011·Cold Spring Harbor Perspectives in Biology·Donald R Senger, George E Davis
Apr 6, 2011·Journal of Vascular Research·Kayla J Bayless, Greg A Johnson
Jun 21, 2014·BioMed Research International·Anna NeveDomenico Ribatti
Aug 3, 2012·Blood·Ripla Arora, Virginia E Papaioannou
Nov 4, 2016·International Journal of Molecular Sciences·Maurizio MongiatAlice Paulitti
Mar 31, 2007·Circulation Research·Laurent LamaliceJacques Huot
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·Divya PankajakshanLissy K Krishnan
Jan 30, 2008·Birth Defects Research. Part C, Embryo Today : Reviews·George E DavisAmber N Stratman
Jun 19, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Jia-Jia Bi, Li Yi
Jun 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Konrad SchwefelMatthias Rath
May 28, 2020·International Journal of Molecular Sciences·Eva AndreuzziMaurizio Mongiat
Oct 30, 2016·The American Journal of Pathology·Sushmita GhatakBeate Eckes
Sep 29, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shomron Ben-Horin, Ilan Bank
Aug 17, 2021·Lab on a Chip·Makena L EwaldChristopher C W Hughes
Sep 3, 2008·The International Journal of Biochemistry & Cell Biology·Antoine R Ramjaun, Kairbaan Hodivala-Dilke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.