Functional Overload Enhances Satellite Cell Properties in Skeletal Muscle

Stem Cells International
Shin FujimakiTomoko Kuwabara

Abstract

Skeletal muscle represents a plentiful and accessible source of adult stem cells. Skeletal-muscle-derived stem cells, termed satellite cells, play essential roles in postnatal growth, maintenance, repair, and regeneration of skeletal muscle. Although it is well known that the number of satellite cells increases following physical exercise, functional alterations in satellite cells such as proliferative capacity and differentiation efficiency following exercise and their molecular mechanisms remain unclear. Here, we found that functional overload, which is widely used to model resistance exercise, causes skeletal muscle hypertrophy and converts satellite cells from quiescent state to activated state. Our analysis showed that functional overload induces the expression of MyoD in satellite cells and enhances the proliferative capacity and differentiation potential of these cells. The changes in satellite cell properties coincided with the inactivation of Notch signaling and the activation of Wnt signaling and likely involve modulation by transcription factors of the Sox family. These results indicate the effects of resistance exercise on the regulation of satellite cells and provide insight into the molecular mechanism of satellit...Continue Reading

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Citations

Oct 19, 2017·International Journal of Molecular Sciences·Shin Fujimaki, Tomoko Kuwabara
Feb 2, 2018·Medicine and Science in Sports and Exercise·Birgit Friedmann-BetteAlexander Barié
Apr 14, 2018·Exercise and Sport Sciences Reviews·Kimberly A Huey

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Methods Mentioned

BETA
PCR
protein
electrophoresis

Software Mentioned

ImageJ

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