Functional pathology of human ovarian steroidogenesis: Normal cycling ovary and steroid-producing neoplasms

Endocrine Pathology
H Sasano

Abstract

In human reproductive endocrinology and pathology, it is important to localize the sites of steroid hormone production to obtain a better understanding of steroid metabolism. Previous approaches, including morphological and biological studies, could not sufficiently demonstrate which cells produce what steroids in both normal and pathological human ovaries. Recent development of immunohistochemistry and in situ hybridization of the enzymes specifically involved in sex steroid biosynthesis made it possible to detect the expression of steroidogenic enzymes, and subsequently the sites of specific steroid production in diagnostic pathology materials. There are, however, some limitations in the approaches, including correlation of the findings with preoperative systemic hormonal manifestations in the patients with sex cord-stromal tumors of the ovary, and great care should be taken when interpreting results.

References

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Citations

Mar 21, 1998·Pathology International·Y KuriharaY Tsutsumi
May 1, 2007·Expert Review of Endocrinology & Metabolism·Hironobu SasanoTakashi Suzuki
May 14, 1998·Clinical Endocrinology·H SasanoN Harada
Jun 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Hironobu SasanoTakuya Moriya
Mar 3, 2009·Annals of the New York Academy of Sciences·Hironobu SasanoTakashi Suzuki
Sep 1, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H SasanoN Harada
Jun 12, 1999·Circulation Research·N HaradaY Takagi
Oct 16, 2007·Breast Cancer Research and Treatment·Ashok SubramanianKefah Mokbel
Oct 31, 1998·Breast Cancer Research and Treatment·H Sasano, H Murakami
Feb 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·H MurakamiH Sasano

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