Functional performance and quality of life in high-risk comorbid patients undergoing transcatheter aortic valve implantation for symptomatic aortic valve stenosis

European Heart Journal. Quality of Care & Clinical Outcomes
Nick HiltropChristophe Dubois

Abstract

We assessed the impact of transcatheter aortic valve implantation (TAVI) on functional performance and quality of life (QoL) in a high-risk patient population with multiple comorbidities. Between January 2009 and December 2014, 145 high-risk patients (EuroSCORE II 7.3% [4.9; 14.9]) with severe symptomatic aortic valve stenosis (AS) underwent TAVI in a single centre. We prospectively evaluated New York Heart Association (NYHA) functional class, 6-minute walking distance (6MWD), and QoL using the validated Dutch version of the EuroQol-5D (EQ-5D) descriptive assessment and a visual analogue scale (EQ-VAS) at baseline, 30 days, as well as 6, 12, and 24 months after TAVI. All patients were eligible for analysis. New York Heart Association functional class improved significantly at 30-day, 6-, 12-, and 24-month follow-up (P < 0.001 for all). The absolute 6MWD improved significantly at 30 days (+19.3 ± 8.2 m; P= 0.0499) and at 6 months (+23.3 ± 8.1 m; P = 0.0194). A favourable trend was maintained at 12 months (+17.1 ± 8.8 m; P = 0.1879), whereas at 24 months 6MWD was similar to baseline values. No significant change in the descriptive assessment of QoL (EQ5D) was observed, whereas the EQ-VAS showed a significant improvement in QoL up...Continue Reading

References

Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·P L Enright, D L Sherrill
May 20, 2003·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Philippe MichelUNKNOWN EuroSCORE Project Group
Sep 21, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Claudia FiorinaLivio Dei Cas
Feb 24, 2009·Lancet·Blase A Carabello, Walter J Paulus
Jul 9, 2009·The Annals of Thoracic Surgery·Sean M O'BrienUNKNOWN Society of Thoracic Surgeons Quality Measurement Task Force
Jan 30, 2010·Health and Quality of Life Outcomes·Matthew T D DyerMartin J Buxton
Nov 16, 2010·European Heart Journal·Thierry LefèvreUNKNOWN PARTNER EU Investigator Group
Apr 9, 2011·American Heart Journal·Rodrigo BagurOlivier F Bertrand
Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators
Aug 2, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michael GotzmannAndreas Mügge
Mar 2, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Samer A M NashefUlf Lockowandt
May 5, 2012·Journal of the American College of Cardiology·Timothy A FairbairnJohn P Greenwood
Aug 28, 2012·European Heart Journal·UNKNOWN Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC)Marian Zembala
Sep 26, 2012·European Heart Journal·Andreas W SchoenenbergerPeter Wenaweser
Jun 13, 2013·European Journal of Preventive Cardiology·Nicola RussoFabio Bellotto
Dec 3, 2013·Journal of the American College of Cardiology·Jonathan AfilaloDaniel E Forman
Apr 15, 2014·Annals of Internal Medicine·Caroline A KimDae Hyun Kim
Feb 7, 2015·Heart·Claire BouletiAlec Vahanian

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Citations

Jul 1, 2016·European Heart Journal. Quality of Care & Clinical Outcomes·Bernard Iung

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