Functional plasticity of macrophages: reversible adaptation to changing microenvironments

Journal of Leukocyte Biology
Robert D Stout, Jill Suttles

Abstract

There has been substantial research activity in the past decade directed at phenotyping macrophage lineages and defining macrophage functional subsets or patterns of activity. The emphasis over the past 2-3 years has been to divide macrophage functional patterns into type 1 (Th1-driven) or type 2 (Th2-driven) functions. However, a huge array of environmental factors (including cytokines, chemokines, pattern recognition receptors, hormones) differentially regulates macrophage response patterns, resulting in the display of numerous distinct, functional phenotypes. Upon stimulation, a macrophage does not display just a single set of functions but rather displays a progression of functional changes in response to the progressive changes in its microenvironment. The remarkable ability of monocytes and tissue macrophages to adapt to changes in their microenvironment challenges the thesis that macrophages displaying unique tissue-specific or response-specific, functional patterns represent distinct lineages. With the exception of mature osteoclasts and mature dendritic cells, evidence supporting stable differentiation as the basis for macrophage functional heterogeneity is equivocal. The concept of whether macrophages develop into fun...Continue Reading

References

Feb 1, 1992·Current Opinion in Immunology·S GordonS Clarke
May 1, 1997·Frontiers in Bioscience : a Journal and Virtual Library·R D Stout, J Suttles
Mar 20, 1998·Advances in Immunology·A J McKnight, S Gordon
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C D MillsA M Hill
Oct 25, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S W FoxT J Chambers
Mar 29, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Terence M DohertyTripathi B Rajavashisth
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Roland LangPeter J Murray
Sep 25, 2002·Journal of Neuroscience Research·Kenji F TanakaMakoto Sawada
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Oct 29, 2002·International Immunopharmacology·Jeroen Visser, Lex Nagelkerken
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Bin Liu, Jau-Shyong Hong
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Jan 30, 2003·Journal of Leukocyte Biology·David M Mosser
May 16, 2003·Nature·William J BoyleDavid L Lacey
Jun 27, 2003·BMC Immunology·Christine A WellsDavid A Hume
Nov 13, 2003·Journal of Leukocyte Biology·Gilles J Guillemin, Bruce J Brew
Dec 6, 2003·Science·Gerd Kempermann, Harald Neumann
Apr 23, 2004·Trends in Pharmacological Sciences·Jacques De KeyserNadine Wilczak

❮ Previous
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Citations

Aug 5, 2010·Inflammatory Bowel Diseases·Isabelle OlivierHélène Eutamène
Jul 23, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Selma Giorgio
Jul 19, 2013·Seminars in Immunopathology·Evelyn GuiradoGilla Kaplan
Dec 8, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kenneth Wilfried KrossHans Jørgen Aarstad
Dec 4, 2013·Annals of Biomedical Engineering·Nassir Mokarram, Ravi V Bellamkonda
Jun 11, 2009·Journal of Clinical Immunology·Nilanjana BanerjeeAshok K Giri
Mar 16, 2012·Immunologic Research·Subhra K BiswasJyue-Yuan Lim
Apr 20, 2005·Placenta·R H McIntire, J S Hunt
Aug 4, 2009·Chemical Research in Toxicology·Debra L Laskin
Nov 10, 2010·Immunology and Cell Biology·Clare Y SlaneyJacquie L Harper
Jun 10, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M KováčikováV Štich
Oct 11, 2011·Nature Reviews. Immunology·Ajay ChawlaY P Sharon Goh
Oct 15, 2011·Nature Reviews. Immunology·Peter J Murray, Thomas A Wynn
May 9, 2007·The Journal of Experimental Medicine·Ludovic ArnoldBénédicte Chazaud
Dec 9, 2008·Antioxidants & Redox Signaling·Milton HamblinY Eugene Chen
Dec 13, 2005·Critical Care Medicine·Jean-Marc Cavaillon, Minou Adib-Conquy
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Anne BouloumiéRudi Busse
Dec 23, 2008·Exercise and Sport Sciences Reviews·Bénédicte ChazaudFabrice Chretien
Jun 17, 2008·Applied and Environmental Microbiology·Bojana StojkovicSteven R Blanke
Aug 14, 2012·International Journal of Vascular Medicine·Kousei OhshimaMasatsugu Horiuchi
Mar 24, 2012·Journal of Innate Immunity·Preeta Dasgupta, Achsah D Keegan
May 29, 2010·Circulation Research·Ajay Chawla
Jul 3, 2010·American Journal of Respiratory Cell and Molecular Biology·Sandra HodgePaul N Reynolds
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Jul 21, 2010·The Journal of Clinical Investigation·Hongxia Z ImtiyazM Celeste Simon
Jun 19, 2012·BMC Immunology·Dapeng GongNora Heisterkamp
Dec 20, 2011·Journal of Translational Medicine·Moniek Heusinkveld, Sjoerd H van der Burg
Aug 4, 2005·Virology Journal·Svend Ellermann-Eriksen
Jul 17, 2009·Journal of Leukocyte Biology·Robert D StoutJill Suttles
Jan 21, 2011·Journal of Leukocyte Biology·Peter J Murray, Thomas A Wynn
Dec 13, 2006·Journal of Leukocyte Biology·Justin I OdegaardAjay Chawla

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